Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Research training projects in the MCBIM group - Bachelor and master students of all chemistry related studies are more than welcome to take part in our research activities. We have various research projects, all in one way or another involving transition metal ions. Daily supervision in the laboratory…

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

This dissertation reports on the pedagogical content knowledge (PCK) of science teachers during a professional development program. This research intended to help us understand why and how teachers make their classroom decisions as they teach science.

SAILS aims to forge links between the different disciplines at the University and to initiate new academic partnerships.

The Biology programme offers 4 research-oriented specialisations corresponding with the research themes within the three institutes involved. You can choose a more practical-oriented specialisation if you would like to combine Biology with education, management business, or science communication.

Read more about the International Network Open Science & Scholarship Communities in our Vision and Mission statements.

Corporate R&D organizations and their relation to academic laboratories.

Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.

The master’s specialisation Bio-Pharmaceutical Sciences and Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical ind…

With a MSc in LST you are well prepared for a wide range of career opportunities. Life Science research and business is one of the fastest growing economic activities worldwide.

Can we link multiple components from herbal extracts with their biological activities?

The master’s specialisation Bio-Pharmaceutical Sciences and Business Studies at Leiden University combines fundamental and applied research with different aspects of business studies.

This event is in Dutch. De Verenigde Naties hebben 11 februari uitgeroepen tot International Day of Women & Girls in Science. De Universiteit Leiden viert deze dag met een open publieksevenement met vrouwelijke topwetenschappers van haar bètafaculteit. Iedereen is welkom vanaf 13:30 uur in het Kamerlingh…

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

This website showcases Leiden University’s contribution to the SSH Sector Plans.

Patterned detectors are an existing technology that can be found in almost all color cameras.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

This UNESCO Chair at CWTS aims to contribute to UNESCO’s agenda to foster diversity and inclusion in science. The chair has two main lines of work:

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

UnMiSSeD studies the interaction between misinformation and science in societal debates using a mixed qualitative-quantitative approach.

Some examples of AI-research done at Leiden.

This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…

There are several training oportunities within the cell observatory

This dissertation describes several studies concerning the research-teaching nexus in the sciences.

Carl Li defended his thesis on 30 June 2015

Our mission: a positive impact. Our vision: community. By involving the world around us in our education and research we make a positive impact. We do this by applying Open Science.

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: G.P. van Wezel

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

My work focuses on a class of astronomical objects called protoplanetary disks.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.