School of pharmaceutical sciences, University of Geneva - Switzerland

This article offers a typology for organizational and institutional crisis management that portrays three sorts of crises: a crisis in an organization, a crisis to the organization and a crisis about the organization.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Promotor: M. Ubbink, Co-promotor: G. Siegal

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: A. Kros

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Using EcoFab 2.0 devices and omics services at JGI, we will examine a plant growth promoting microbial community during interaction with different plant species.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Antimicrobial resistance is one of the biggest threats to human health worldwide in the coming decennia.

The team of WIIS-Netherlands exists out of the board members and the advisory council.

Lecture

A cautious response to a crisis or terrorist act avoids the creation of a culture of fear. This is another way to reduce our vulnerability to terrorism.

Europe is of great importance for Leiden University: as an academic discipline, as a funder for research and education activities, and as a legislator, the EU offers us many opportunities.

This research paper was requested by the European Parliament's Committee on Civil Liberties, Justice and Home Affairs. It was published by the International Centre for Counter-Terrorism (ICCT) in The Hague. Leiden University is one of the participating institutes in this publication and our researcher…

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

If you are interested in Life Science and you are looking for a programme with ample opportunities to put together your own study path, our Life Science and Technology programme is the right choice. The programme focuses on societal problems at the molecular and cellular level.

Grants awarded to molecular physiology research

The Gorlaeus Building will be constructed in three phases, with the new building due to be completed by 2028.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Promotor: B. van de Water

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Promotor: Prof.dr. G.J. Kroes

Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

Promotores: Prof.dr. J. Zaanen & Prof.dr. K.E. Schalm

Promotor: M.A.G.J. Orrit