In the Research in Bio-Pharmaceutical Sciences specialisation you will perform research on various topics in the area of Drug Discovery and Development. The programme offers a high level of flexibility and can be tailored to your scientific interests. The major research project is hosted by the Leiden…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Tot voor kort was de kartering van oppervlaktevondsten de geijkte manier om het in de bronstijd bewoonde gebied in West-Friesland in kaart te brengen. In dit rapport gebaseerd op archeologisch onderzoek in 2012-2015 wordt uiteengezet wat de relatie tussen de oppervlaktevondsten en de aan- en afwezigheid…

What can we learn from how maritime conflicts were managed in the past? What significance did Maritime Conflict Management have in shaping the standards of diplomacy and international law in pre-modern Atlantic Europe (1200-1600)?

Overview of granting opportunities in the wider digital humanities community. Follow links for the most up-to-date details on deadline dates/times and conditions for applying.

City dwellers in the Middle Ages were probably no worse off than people living in villages. Both groups had very different health risks, is Rachel Schats' conclusion from her research on bone material. PhD defence 3 November.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

Examine and experience the material features and characteristic appearances of medieval manuscripts, annotated books, prints, drawings, photographic albums and much more, in various settings.

The Molecular Physiology group collaborates with both international public-private and academic institutions.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

For more information regarding ongoing research projects, please contact Prof. Miranda van Eck.

Currently, more than 80% of drugs are used in an off-label manner in critically ill neonates.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Pathways of toxicity

The Leiden University PhD regulations are leading for the composition of the PhD dissertation. As Leiden University prescribes no strict regulations with regard to the structure and content of a PhD dissertation, LACDR has composed thesis guidelines, specified per research group. At the start of a PhD…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Analysis of drug adversity

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

Source: ChemMedChem (2015)

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Papyrology+, founded in 2014, is a collaboration of Leiden scholars studying (Abnormal) Hieratic, Demotic, Aramaic, Greek, Latin, Coptic, and Arabic papyri from a socio-historical, economic and linguistic perspective. Papyrology+ aims to explore new opportunities and directions in the study of ancient…

University building Campus Spui The Hague

Recently, archeologists of Leiden University made an excavation in Oegstgeest, where they found a unique silver bowl from the first half of the seventh century as well as imported pottery and winebarrels. Thijs Porck, lecturer in Old English language and culture at Leiden University, places the Oegstgeest…

The Hazelhoff Centre for Financial Law team regularly publishes in both Dutch and international academic journals and book series.

Leiden University offers courses about papyri and papyrology for beginners and more advanced students (BA and MA), both based on texts in translation as well as in the original source languages, from Egyptian to Greek, Latin and Arabic.

The conquest by Rome brought profound changes to large parts of Europe. Unprecedented infrastructural works such as roads and harbours were created, towns sprang up, a ribbon of fortresses was laid out along the frontiers and there is a vast increase in material culture to inform us about the lives…

LUCAS members are experts in the fields of literary history and theory, film and media studies, and art, architectural, and book history.

Kyra van der Moezel defended her thesis on 7 September 2016.

Contact information & Visitors address

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

To address major societal challenges, research needs to go beyond the boundaries of traditional disciplines. We believe this starts with education. By exposing students to people from different scientific fields, they learn to deal with diverse perspectives and can broaden their horizons. Professors…

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Review Committees, with cross-boundary experts, are invited to assess our research and education programmes.

In The Holy Land in Observant Franciscan Texts (c. 1480–1650) Marianne Ritsema van Eck analyses the development of the complex Observant Franciscan engagement with the Holy Land during the early modern period.

The journey of sugar from east to west