What can continuity and change in the manufacturing of locally made ceramics from the early colonials Spanish towns of Concepción de la Vega, Cotuí and Nueva Cádiz (1492-1600) tell us about the choices people made in ceramic production as a reaction the the changing social environment?

The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Repairing organs, tissues and cells to fight chronic diseases.

An overview of the research at the Cancer Dug Target Discovery group.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

How did changes in the composition and exploitation of princely domains in various principalities of the Low Countries influence the development of ‘modern’ public finance systems, including the notion of public debt?

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

The Dutch Advisory Committee on Public International Law has, on its own initiative, provided advice to the Dutch government regarding the duty of third states to prevent genocide under the Genocide Convention. The Committe's advice addresses the legal uncertainty in political and societal debates about…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw- Center for Law and Digital Technologies, just published a book on Robots, Healthcare, and the Law. Regulating Automation in Personal Care.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

China is conducting joint military exercises this week with Cambodia, Laos, Malaysia, Thailand, and Vietnam. In doing so, it is seeking to strengthen military ties with the ASEAN Member States amidst growing US presence in the region.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Mandy de Wilde is a lecturer at the Institute of Cultural Anthropology and Development Sociology of Leiden University. The core question driving her work is how ecological sustainability plays out in local practices, and the situated harms as well as the opportunities that emerge from it.

Friso Selten is a Ph.D. candidate in the SAILS project. In this interdisciplinary research project, a collaboration between the Institute of Public Administration, Advanced Computer Science, and eLaw, he investigates the digital transformation of public organisations, with a focus on the J&V-domain.

Erik Kroon is a postdoctoral researcher at the Faculty of Archaeology.

Eleftheria is an assistant professor at the Leiden Institute of Advanced Computer Science (LIACS) since 2023. Her research interests lie mainly in the field of Applied Cryptography, and Privacy Enhancing Technologies; specifically, technologies and applications of Computing on Encrypted Data (e.g.,…

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

One-size-fits-all digital gamification sometimes hinders students’ learning due to the ignorance of individual differences. This project aims to explore how tailored digital gamification can be used in higher education and its effects on university students’ motivation and learning outcomes.

A growing amount of literature is being devoted to interrogating gendered dynamics in both violent extremism and terrorism, contributing to the integration of international and feminist security. This includes how such dynamics can shape differences in the motivations and participation of women and…

In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.

On 5 June, Maarten Aalbers defended the thesis 'The balancing of general interests in EU State Aid Law: blurred lines between the prohibition and the compatibility of aid'. The doctoral research was supervised by Pieter van Cleynenbreugel and Stefaan van den Bogaert.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Following an investigation into plagiarism, Erasmus University Rotterdam has declared the master’s thesis of Dutch State Secretary for Long-term and Social Care, Vicky Maeijer, invalid. Wim Voermans, Professor of Constitutional Law, spoke to Dutch newspaper ‘Trouw’ about the matter.

The overlapping of intergovernmental organizations sharing Member States is one of the key challenges for achieving effective regional integration.

On 7 and 8 July 2016 the T.M.C. Asser Instituut and the Law Faculty of Leiden University organise a two-day symposium on EPPO.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

The applications of studying the early development of insects range from agriculture to material science.

Source: Mediators Inflamm (2014)

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

Dennis Broeders is Full Professor of Global Security and Technology and Senior Fellow of The Hague Program on International Cyber Security at Institute of Security and Global Affairs of Leiden University. His research and teaching broadly focuses on the interaction between international security, technology…

The Hague Diplomacy Podcast aims at bringing the themes of the journal's research off the page, and onto the discussion table. Each episode will feature a guest who will share their insights and personal experience within their practice of or research on diplomacy. Available via SoundCloud, Apple Podcasts…

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

From 26 to 30 June 2017 a summer course on Europeanisation of administrative law in the Member States of the European Union will be held by the Department of Constitutional and Administrative Law.

This month Johan Christensen, assistant professor at the Institute of Public Administration, published his new book: ‘The Power of Economists within the State’. The book explores four countries, Denmark, Ireland, Norway and New Zealand and analyses why these similarly sized and wealthy countries have…