The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Enabling volume-restricted metabolomics using next-generation microscale analytical tools.

Doctoral Thesis

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Delineating psychophysiological endophenotypes of social anxiety disorder

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotores: W. Jiskoot, F. Ossendorp

Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.

Does a moving hybrid zone leave a genomic footprint?

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

The portal for prospective Indonesian Students contains information about the possibilities to study at Leiden University in the Netherlands.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

A seven-metre glass tunnel, filled with running water, and equipped with speakers and cameras. An artificial river for investigating what light and sound pollution do to migrating fish.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

When you apply for admission, you’ll be asked to submit several documents.

The Leiden Institute of Physics (LION) offers bachelor and master level education in physics at Leiden University.

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Are you currently studying medicine and considering the master's Health, Ageing and Society? Read more about what the master's programme can mean for you!

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

proefdieren dierproeven universiteit leiden geneesmiddelonderzoek geneesmiddelen

PhD defence

Martin van Hecke en Anne Meeussen publiceren in het tijdschrift Nature over mechanische metamaterialen. Ze hebben een nieuwe klasse multistabiele materialen ontdekt. Dit is gebaseerd op ribbeltjes plastic.

Salt crystals, a nano-sized golf stick and molten glass. The LION Image Award competition of 2023 yielded a lot of beautiful images once again. But in the end, only one can be the winner.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.

In a lot of research on education, general didactic principles are applied to a particular area of study. ‘But every field of study also has its own ways of thinking’, argues professor Fred Janssen. ‘If you can identify those ways of thinking, then you have a lot of indicators for how you can best organise…

Bubble baths and face masks: that’s what we often see on social media when discussing self-love. However, is this a true reflection of what self-love and self-care entail? In this episode, psychotherapist Kelly Ziemer teaches us more about what true self-love and self-care are, and their importance.

PhD defence

PhD defence

The civil lawsuit against the Congregation of 'Onze Lieve Vrouw van Liefde van de Goede Herder' starts this week. A total of 19 women, aged from 62 to 91, together with the women’s rights foundation Clara Wichmann wants recognition through the courts that there was a situation of forced labour at youth…

Jeugdhulpinstanties zijn ernstig tekort geschoten bij hulp aan het mishandeld pleegmeisje uit Vlaardingen, blijkt uit nieuw onderzoeksrapport. Hoogleraar jeugdrecht Mariëlle Bruning schoof aan bij Nieuwsuur: ‘Het gaat om extreem menselijk falen.’

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

The research group Science Communication and Society has been physically within the Institute of Biology (IBL) since 2012 and has become a formal part of the institute in 2018. The mission of this group is understanding how science communication works to improve the interaction between science and s…

Exploring the landscapes of mental health and cardiometabolic research.

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

How can we monitor and protect biological and cultural diversity in Suriname best? What can we learn from local knowledge and customs associated with biodiversity? How can we understand current species, acoustical, behavioural, and ecological diversity from an evolutionary perspective? Can we predict…

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Five talks will be given during the Leiden Science Family Day: two children's lectures and three lectures for adults. Will you be there ?