Formulation of biopharmaceuticals

Promotor: A.P.IJzerman Co-promotor: A. Bender

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Discovery of metastasis promoting candidate drug targets

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

During the course of drug discovery translational steps are made.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The specialisation enables you to understand the fundamentals of management and entrepreneurship alongside high quality Bio-Pharmaceutical research at a world class institute.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

This thesis discusses the development in Proto–Indo–European, Latin and Romance of a word–formation pattern which the most adequate terminology in use dubs ‘verbal government compounds with a governing first member’; I use the shorthand ‘pickpocket compounds’.

Ariadne Schmidt, Isabelle Devos and Julie de Groot provide you with refreshing insights concerning the study on urban singles in the period between 1200 and 1900.

The following sources were consulted for this guide:

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Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Our education programmes span the entire spectrum of Animal Sciences, Evolution, Biodiversity and Conservation, Microbial Biotechnology and Plant Sciences.

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Leer meer over de Master Education and Child Studies tijdens de Online Master's Open Dagen van de Universiteit Leiden.

FAIR-ASSESS brings together researchers from five different Leiden faculties, as well as experts from outside the university. The project has been initiated by Andrei Poama and is being led by Josette Daemen.

Until 2019, LUCIS hosted one annual lecture, inviting an eminent scholar to give a large-scale lecture in one of the finer halls at Leiden University. Because of their success, we now organise four larger lectures every year, entitled LUCIS Keynotes.

In his groundbreaking Imagined Communities, first published in 1983, Benedict Anderson argued that members of a community experience a

This publication by Cornelis van Tilburg, will be published at Sidestone Press on September 28, 2022. It discusses various aspects of city gates in the Western Roman Empire: Italy, Spain, Gaul, Germany and Britain.

This dissertation examines how we can reconstruct physical activity by looking at variations in the shape of muscle attachment sites ( ‘entheses’) on the human skeleton. It evaluates two post-medieval contexts; rural Middenbeemster and urban Aalst.

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2016.

The archaeology domain produces large amounts of texts, too much to effectively read or manually search through for research. To alleviate this problem, we created a search system (called AGNES), which combines full text search with entity and geographical search.

This comparative study investigates court politics in four kingdoms that succeeded the south Indian Vijayanagara empire during the sixteenth to eighteenth centuries: Ikkeri, Tanjavur, Madurai, and Ramnad. Building on a unique combination of unexplored Indian texts and Dutch archival records, this research…

This dissertation assesses the influence of British Celtic on the phonological development of English during and shortly after the Anglo-Saxon settlement period, ca. AD 450-700.

This new volume, published 19 November 2020, - within the series 'Intersections' -, explores the concept of magnificence as a social construction in seventeenth-century Europe. Although this period is often described as the ‘Age of Magnificence’, thus far no attempts have been made to investigate how…

The Disticha Catonis by Catenaccio of Anagni. A text in vernacular from Latium (late 13th - early 14th century)

De semantiek van Aristoteles: waarheid en betekenis in het tijdperk van het darwinisme