Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Cardiovascular diseases are still a major concern for the global health.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

Promotor: Prof.dr. E.J.J. Groenen

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

A selection of recent publications from the Plant BioDynamics Laboratory.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

The research group of Silke Henkes at Leiden University. Part of the Leiden Institute of Physics (LION). The group studies the physics opf active materials.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Mechanisms fro drug resistance

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: J.M. Memelink

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

During the course of drug discovery translational steps are made.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…

Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.

PhD defence

PhD defence

Vera van Noort, professor in Computational Systems Biology at the KU Leuven (Belgium), is appointed holder of the rotating chair “Van der Klaauw Professor” for the year 2015-2016 at the Institute of Biology. Holders of the chair bring inspiring research and teaching in theoretical biology to the University.…

On December 4th, Flor Rhebergen received the 2015 Unilever Research prize for his study achievements at the IBL for his outstanding work in the field of Evolutionary Biology. Flor Rhebergen received the “Ovum” sculpture and was awarded €2.500.

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

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Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

Lecture

PhD defence

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…