Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

PhD defence

PhD defence

PhD defence

To be eligible for Biodiversity and Sustainability at Leiden University, you must meet the following admission requirements.

To be eligible for Biology at Leiden University, you must meet the following admission requirements.

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

To be eligible for Biology and Business Studies at Leiden University, you must meet the following admission requirements.

To be eligible for Molecular, Cellular and Organismal Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Biology and Education at Leiden University, you must meet the following admission requirements.

To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.

To be eligible for Evolutionary Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Biology and Science Communication and Society at Leiden University, you must meet the following admission requirements.

Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)

Grants awarded to molecular physiology research

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

Promotor: Prof.dr. J.W.M. Frenken

Promotor: A.P. IJzerman

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

Source: J Cheminform, Volume 6, Issue 1 (2014)

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Promotor: M.A.G.J. Orrit

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…

Why do plants produces always produced so many slightly differing metabolites within a particular chemical class?

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Source: Eur J Med Chem (2015)

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Source: J Cheminform, Volume 7, Issue 1 (2015)

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.