2,056 search results for “binding study advice bsa” in the Public website
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Behavioural Insights Teams (BITs) and Policy Change
Sarah Giest, Assistant Professor at Leiden University, and Ishani Mukherjee researched the topic of 'Behavioural Insights Teams (BITs) and Policy Change: An Exploration of Impact, Location, and Temporality of Policy Advice'.
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Leiden Study System
At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator
SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.
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Laura HeitmanFaculty of Science
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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CellEKT: a chemical proteomics platform to study the kinome
Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.
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Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
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Minerva in her Study
Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…
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Executive Board decision after University Council advice: People counters will not be switched on again
The more than 370 sensors that have been hung up in Leiden University buildings to count the people present will not be switched on again. The equipment will eventually be removed from the buildings.
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Christopher GreenFaculty of Humanities
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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FragmEndoscopy: Medieval fragments in early modern book spines
During the early modern period, many medieval manuscripts were cut up into strips of parchment which were reused to reinforce the bindings of newly printed books. Until recently, these reused pieces of medieval manuscripts only came to light when the early modern book binding was damaged and/or subjected…
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Elizabeth (Liesbeth) de LangeFaculty of Science
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The Advisory Roles of Political Scientists in Europe
Arco Timmermans, professor by special appointment in Public Affairs at the Institute of Public Administration, is co-editor of this book focused on comparing engagements in policy advisory systems.
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Advice on Legal Obligation of Third States to Prevent Genocide
The Dutch Advisory Committee on Public International Law has, on its own initiative, provided advice to the Dutch government regarding the duty of third states to prevent genocide under the Genocide Convention. The Committe's advice addresses the legal uncertainty in political and societal debates about…
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Nico KapteinFaculty of Humanities
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Peter VerhagenFaculty of Humanities
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Ab de JongFaculty of Humanities
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It's about time
This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Boudewijn WalravenFaculty of Humanities
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Xiao LuoFaculty of Humanities
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Haneen OmariFaculty of Humanities
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Maghiel van CrevelFaculty of Humanities
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synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
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AIV advice on hybrid threats and societal resilience
On 2 April 2025, Anna Marhold, a member of the Peace and Security Committee of the AIV and Assistant Professor at the Grotius Centre for International Legal Studies, joined a technical briefing to parliament providing advice on hybrid threats and societal resilience.
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Gert Jan Geertjes defends preliminary advice Nederlandse Vereniging voor Wetgeving
At the annual conference of the Nederlandse Vereniging voor Wetgeving (the Dutch association for legislation) that was held in the Auditorium of the Ministries of Internal Affairs and Kingdom Relations and Justice and Security in The Hague on Thursday 6 October, Gert Jan Geertjens defended the draft…
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Henk Schulte NordholtFaculty of Humanities
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Shirley AlexanderFaculty of Humanities
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Francesca RosatiFaculty of Humanities
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Geoffrey CainFaculty of Humanities
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Steven HagersFaculty of Humanities
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Valérie PattynFaculty of Governance and Global Affairs
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Edegar Da Conceição SavioFaculty of Humanities
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Crewe WilliamsFaculty of Humanities
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Amirardalan EmamiFaculty of Humanities
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Xiong XiongFaculty of Humanities
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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Caroline Fernandes CaromanoFaculty of Humanities
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Marat MarkertFaculty of Humanities
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Judith FrishmanFaculty of Humanities