With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The focus of health care is rapidly changing. The need for maximum gains with minimal input requires tailored health care strategies and an ever more explicit evaluation of health benefits for the patient.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

NimbleAI aims at solutions for ultra-energy efficient and secure neuromorphic sensing and processing at the edge.

The active learning ambition is based on the idea that knowledge is more likely to ‘stick’ when students are actively engaged with their learning and research. This active student participation has implications for how we teach: less consumption of knowledge and more efficient use of contact hours.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Using photosynthesis to generate energy, or using enzymes to effectively produce biofuel; Leiden chemists Huub de Groot en Hermen Overkleeft have both obtained an NWO TOP funding for their pioneering research. With the money they can take on new PhD students.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

Promotor: K.J. Batenburg

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Artificial intelligence could help make the work of public sector organisations, professionals, policy- and decision makers more effective, more efficient, and ideally could make it more rationalised and evidence-based.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotores: J.N. Kok, H.J. Hoogeboom

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

What political factors affect the speed or duration of EU legislative decision-making?

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotor: Prof.dr. E. Deprettere

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

Cyber security is one of the critical challenges in our inter-connected world. Organizations are being constantly targeted by adversaries. Various critical systems become exposed on the Internet. Users can find that their data has been stolen from a company that they were not even aware of.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This article argues that opposition to government green investments is conditional on the method of financing.

Lecture

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Urbanization brings benefits like housing and jobs but also challenges like biodiversity loss. CML's Urban research program uses science to create sustainable cities, focusing on the built environment (circular economy, urban mining) and enhancing urban nature for biodiversity and human benefits.

SuperCode: Sustainability PER AI-driven CO-DEsign

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Can Cyanobacteria be engineered to convert the greenhouse gas carbon dioxide into the valuable chemical isoprene?

Advances in the field of high-performance Nd-Fe-B permanent magnets, by re-engineering their microstructure to make them more powerful while reducing rare earth content.