Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

PhD defence

Book on Dutch mayors governing local order and public safety.

Emma de Vries, PhD researcher at LUCAS, has been awarded with a Fulbright Grant and Prins Bernhard Cultuurfonds Scholarship. From September 2015 onwards, Emma will spend a full academic year in the Unites states, to work at UCLA and Harvard on her PhD research on Neo-Epistolarity.

Leiden alumnus and writer Tomas Lieske has published a novel which is set in the house of Paul Ehrenfest. Ehrenfest was a famous physicist who organized round table events every Wednesday evening at his home in Leiden in the early twentieth century. The big names from modern physics frequented these…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Prostate cancer (PCa) is one of the most prevalent cancer in males.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

In my research I am concerned with the possibility of a politics of sexuality without reverting to identitarian conceptions of sexuality. In a reading of the work of the American author James Purdy, I propose to move towards a politicizing of the concept of narrative identity as developed by the French…

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

World War II is never over for those who have lived through it. This is the conclusion of Cleveringa Professor Carol Gluck and her students after reading The Assault (De Aanslag) by Harry Mulisch. The book played a central role in Gluck’s honours course.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Sonic Modernities situates Southeast Asian popular music in specific socio-historical settings, hoping that a focus on popular culture and history may shed light on how some people in a particular part of the world have been witnessing the emergence of all things modern.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

What does an unequal society lead to if it's not responded to by politicians? What happens when people are no longer waiting for something good to happen to them? An international perspective can give us possible answers.

The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

How to understand the simultaneously dis- and reappearance of letters in contemporary culture, and how does this Neo-Epistolarity relate to media-technological change?

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.

You can find more information on the Dutch webpage. Click on the “Nederlands” button above.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

In the International Studies programme, you will develop the knowledge as well as the critical insights needed to gain regional expertise within a global context. In addition, you will acquire the practical and professional skills that will assist you in making your first steps in your career, whether…

The Hans Franken Lecture honors the legacy of Prof. Dr. Mr. Hans Franken, a founding figure of eLaw in 1985.

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

Key publications of the Predictive Pharmacology group.

As an R&D manager, how can you measure the R&D (research and development) performance of your firm? How does knowing the importance of different R&D measures allow R&D managers to formulate more effective strategies to improve their firm’s R&D performance?

Leiden University and the city of The Hague are working closely together to increase the impact of our research and education in order to contribute as much as possible to the development of the city.

What mechanisms shape faculty members' perspectives on their teaching role in research intensive universities?

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Globalisation is shaping the world in which we live. In the BA International Studies, you have the opportunity to study one of eight world regions within the context of global interactions. At the same time, you will learn a key language of your chosen region and acquire skills that will prove to be…

Are the types of school non-attendance which have been evidenced in typically developing youth also found among children and adolescents with an intellectual disability (ID)? If so, which types are most prevalent and thus in greatest need of attention, and what factors (child, family, school/environmental)…

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…