How are the epidermal lipid pathways involved in health and disease.

description that google uses to depict when in presented in search results

Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

Key publications of the Skin Barrier and Vaccination group.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.

Four thousand visitors immersed themselves in art and science during Leiden's Night of Art and Science on 17 September. They could choose from dozens of lectures, experiments, interactive events and a lot of art.

In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

Not ten but fifty Covid vaccines from one vial. This is possible if the vaccination is delivered into the skin rather than the muscle, research by internist and infectious disease specialist Anna Roukens from the LUMC has shown. EenVandaag reported on this important discovery, which could have huge…

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

A semi-empirical version of the specific reaction parameter approach to density functional theory (SRP-DFT) has been remarkably successful at predicting dissociative chemisorption probability vs. incidence energy curves for reactions on metal surfaces. New quantum Monte Carlo (QMC) calculations on the…

And its application in deciphering hominin diets in palaeolithic eurasia

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

One of the objections to the Comprehensive Economic and Trade Agreement between Canada and Europe (Ceta) is that countries would be surrendering national sovereignty to multinationals which will obstruct effective climate policy. But compared to other trade agreements, CETA is an improvement.

eLaw colleagues Bart Custers and Helena Ursic have a new publication in the peer-reviewed journal The European Data Protection Law Review.

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Sylvia van Beugen has won the Herman Musaph Literature award 2016 for the best publication about psychodermatology. Her publication describes the importance of body awareness in chronic skin conditions, such as psoriasis.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

Physicists have studied the astrophysical neutrino signal as reported by the IceCube collaboration from a different angle with their ANTARES detector. The Milky Way centre was an obvious prime suspect to be a source, but this hypothesis is now only closer to debunked than confirmed. Publication in Physical…

Tineke Berkers has won an award for outstanding contribution for her poster at the Gordon Research Conference at Waterville Valley, USA.

Vaccination via the skin or the mucosae

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

In March, Dutch universities will take staggered strike action against the planned cuts. The strike will begin in Leiden on Monday 10 March. The university supports the strike action but is not going to close that day. Below we inform you how the strike will affect our university, students and staff…

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

The Move-In Days will take place on 15-16 August 2026. In order to prepare yourself for your Move-In Day, we want to share with you some more info, and what to expect before this date. DUWO - our student housing partner that deals with LUC's housing will be in touch with you in the summer to start…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Hiring commercial consultancy firms by (local or regional) authorities remains controversial and it is at the centre of attention. This was previously revealed in an investigation carried out by Dutch television programme ‘Nieuwsuur’. Dutch news platform Binnenlands Bestuur also sheds light on this…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

In this article, Friso Selten and Bram Klievink explore how public organisations strategically manage the adoption of AI.