Key publications of the Cancer Drug Target Discovery group

Promotor: E. Bouwman, Co-promotor: S. Bonnet

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

PhD at Université de Picardie Jules Verne, Amiens - France

Master projects are available in

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Supervisor: Indira Nederpelt

New or improved treatments for chronic and acute illness.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

How can the emergence of primary justice systems be facilitated and furthered?

GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services

Visualising structures of life

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Microbial Sciences' contribution to the Biodiversity & Evolution research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

How should we address our colonial heritage? And how digital and accessible are our collections? Outgoing State Secretary Fleur Gräper spoke with researchers and heritage specialists about this on 25 January.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?

Esteban Szmulewic , PhD candidate at the Constitutional and Administrative Law Department has written a paper on the comparison between Italy and the Netherlands, covering the first part of the pandemic (2020 and early 2021). The article has been published in the prestigious 'Journal Diritto Publico…

On Thursday 28 January 2016, Prof. Carsten Stahn contributed to the OPCW Sub-Working Group on Non-State Actors, together with Professors Andrew Clapham (Geneva) and Dapo Akande (Oxford), in the presence of the Ahmet Üzümcü, Director-General of the OPCW.

On 30 January, GTGC hosted a special event together with the Embassy of Ireland. As part of his visit to the Netherlands, John Concannon, Director General of the Global Ireland Unit of the Irish Department of Foreign Affairs, came to the university to engage in a discussion about Ireland's role in international…

The Netherlands will comply with the arrest warrant issued by the International Criminal Court (ICC) against Netanyahu and proceed to arrest him as soon as he enters Dutch territory. Jens Iverson,Assistant Professor of Public International Law, discusses the issue in Dutch daily newspaper ‘Trouw’.

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.