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1,968 search results for “binding study advice bsa” in the Public website

• Congruence between voters and parties: The role of party‐level issue salience Research output

  The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.

• Allosteric Modulation Research project

  Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

• allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action Research output

  Source: Mediators Inflamm (2014)

• Kinetic profiling of positive allosteric modulators of the mGlu2 receptor Research project

  Supervisor: Maarten Doornbos

• Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor Research project

  Supervisor: Lizi Xia

• University Council Elections 2025 Leiden University Green Office

  With the University Council elections approaching, the Leiden University Green Office (LUGO), with the support of LU's Central Sustainability Team and the D&I Office, contacted all seven candidate parties to inform our community about their views on sustainability and diversity. We asked each party…

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  Kiyan Foroutan PhD Candidate

  Faculty of Humanities

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  Hélène Nut External PhD candidate

  Faculty of Humanities

• 
  Shuqi Jia PhD candidate

  Faculty of Humanities

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  Irene Hadiprayitno University Lecturer International Studies

  Faculty of Humanities

• Supercritical carbon dioxide spray drying for the production of stable dried protein formulations Research output

  Promotor: W. Jiskoot, Co-promotor: H.A. Every

• From every angle: novel insights into CC chemokine receptor 2 pharmacology Research output

  The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

• Synthetic carbohydrate ligands for immune receptors Research output

  One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

• Author, Reader, Book: Medieval Authorship in Theory and Practice Research output

  This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.

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  Jelle Bruning University Lecturer Middle Eastern Studies / Arabic

  Faculty of Humanities

• 
  Yujing Tan Lecturer

  Faculty of Humanities

• Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates Research output

  We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

• Intracellular allosteric modulators for human CC chemokine receptors Research project

  Supervisor: Natalia Ortiz Zacarías

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  Maurits Berger Professor

  Faculty of Humanities

• 
  Nathal Dessing University Lecturer Anthropology of Religion

  Faculty of Humanities

• 
  Guita Winkel Guest

  Faculty of Humanities

• 
  Shahab Daneshvar PhD candidate

  Faculty of Humanities

• 
  Daný van Dam University Lecturer

  Faculty of Humanities

• 
  Mubarika Nugraheni PhD Candidate

  Faculty of Humanities

• 
  David Henley Professor

  Faculty of Humanities

• 
  Erik-jan Zurcher Professor emeritus

  Faculty of Humanities

• University outlines approach to responsible collaboration following advice of Committee on Human Rights News - 23 April 2026

  Leiden University is announcing its approach to sensitive collaboration with external partners.

• Allosterism Cell Systems and Drug Safety

  The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

• Computational Drug Discovery

  Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

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  Edmund Amann Professor

  Faculty of Humanities

• Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands Research project

  Supervisor: Andrea Martella

• The synthesis of mannose-derived bioconjugates and enzyme inhibitors Research output

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

• Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides Research output

  The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

• Enzyme-substrate interactions in the processive enzyme xylanase Research output

  The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

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  Tim Wuisman Tutor Bachelor Security Studies

  Faculteit Governance and Global Affairs

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  Léon Buskens Director NIMAR

  Faculty of Humanities

• Focus on kinetics for better drug development News - 4 April 2017

  Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

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  Roelie Mol Policy officer

  Faculty of Humanities

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  Saskia Goedhard Executive Director Faculty of Humanities

  Faculty of Humanities

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  Marjon Smeets Management assistant faculty board

  Faculty of Humanities

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  Roxana Rossel Helwegen Management assistant faculty board

  Faculty of Humanities

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  Anne Zwetsloot Policy officer

  Faculty of Humanities

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  Maarten Bergwerff Policy Officer

  Faculty of Humanities

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  Aphroditi Zoulfoukaridis Manager LeidenGlobal

  Faculty of Humanities

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  Myrte Vos Policy officer research data

  Faculty of Humanities

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  Annemarie Bibo Board secretary

  Faculty of Humanities

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  Ali Shobeiri Assistant Professor

  Faculty of Humanities

• ‘Take medicine target saturation into account’ News - 25 January 2019

  Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

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  Weishuo Li PhD candidate

• Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors Research project

  Supervisor: Xue Yang