2,056 search results for “binding study advice bsa” in the Public website
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Arie van der KooijFaculty of Humanities
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Staff symposium on student well-being: ‘Building on a healthy, engaged and learning community’
Over 200 staff from Leiden University discussed student well-being with one another and students at the Staff Symposium on Student Well-being. In various workshops and lectures, lecturers, student advisers, student counsellors and other staff members discussed how they could contribute to our students’…
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Executive Board of the University asks University Council for advice on activating person counters/sensors
The Executive Board of Leiden University has asked the University Council to advise on its proposed decision to reactivate the person counters/sensors in due course. The Council will now look at this carefully before the Board makes a final decision. The advice of the University’s participation body…
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Berthe JansenFaculty of Humanities
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Allosteric Modulation
Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…
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Paula Esteves dos Santos Jordao -
Kiyan ForoutanFaculty of Humanities
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Hélène NutFaculty of Humanities
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Sarah HolmaFaculty of Humanities
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Shuqi JiaFaculty of Humanities
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Irene HadiprayitnoFaculty of Humanities
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Kinetic profiling of positive allosteric modulators of the mGlu2 receptor
Supervisor: Maarten Doornbos
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Christian HendersonFaculty of Humanities
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Congruence between voters and parties: The role of party‐level issue salience
The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.
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University Council Elections 2025
With the University Council elections approaching, the Leiden University Green Office (LUGO), with the support of LU's Central Sustainability Team and the D&I Office, contacted all seven candidate parties to inform our community about their views on sustainability and diversity. We asked each party…
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Jelle BruningFaculty of Humanities
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Maria RiepFaculty of Archaeology
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From every angle: novel insights into CC chemokine receptor 2 pharmacology
The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Yujing TanFaculty of Humanities
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Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every
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Nathal DessingFaculty of Humanities
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Daný van DamFaculty of Humanities
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Mubarika NugraheniFaculty of Humanities
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Shahab DaneshvarFaculty of Humanities
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Guita WinkelFaculty of Humanities
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Erik-jan ZurcherFaculty of Humanities
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David HenleyFaculty of Humanities
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Author, Reader, Book: Medieval Authorship in Theory and Practice
This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.
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Deniz TatFaculty of Humanities
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Elpine de BoerFaculty of Humanities
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…
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Intracellular allosteric modulators for human CC chemokine receptors
Supervisor: Natalia Ortiz Zacarías
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Mahmood YenkimalekiFaculty of Humanities
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Edmund AmannFaculty of Humanities
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Michael HerzfeldFaculty of Social and Behavioural Sciences
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Tim WuismanFaculty of Governance and Global Affairs
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Léon BuskensFaculty of Humanities
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Allosterism
The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
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Enzyme-substrate interactions in the processive enzyme xylanase
The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.
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Roelie MolFaculty of Humanities
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Aphroditi ZoulfoukaridisFaculty of Humanities
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Maarten BergwerffFaculty of Humanities