850 search results for “efficient medicijnontwikkeling” in the Public website
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Network and projects
Netwerk en projecten duurzaamheid verduurzaming green office en green team
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Spin transport and superconductivity in half-metallic nanowires and junctions
The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.
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Large-scale Computing Infrastructure
Large-scale computing infrastructure, such as supercomputers, cluster, and clouds, are already pervasive, most members of our society interact with them daily: social networks, government services, media streaming services--all systems heavily interfacing with the members of our society--are powered…
- Green roofs and Buildings
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The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
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Virtual Photography. Artificial Intelligence, In-game, and Extended Reality
While it has traditionally been seen as a means of documenting an external reality or expressing an internal feeling, photography is now capable of actualizing never-existed pasts and never-lived experiences.
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Studies into electrochemical hydrogenation reactions using molecular catalysts
The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.
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LEAF
Leiden University encourages all its laboratories to obtain LEAF (Laboratory Efficiency Assessment Framework) accreditation.
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Electrolysis and fuel production
Electrolysis is a technique that can be used to convert CO2 into fuels and other useful products. To do this efficiently and on a large scale, however, we need to understand exactly how electrolysis works. Professor Marc Koper is an expert in this field.
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Redox catalysis for a sustainable energy infrastructure
The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…
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Study programme
The EG track is built on the foundation of MPA courses in which you gain understanding of the complexities of public institutions and acquire advanced academic skills. Specialisation courses focus on the welfare state, markets and competition, and political economy.
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Materials-GRoWL: Gauging the Rest-of-the-World’s Lifecycles of Construction Materials
What types of construction materials are used in the Global South, where are they, and what levels of societal services do they support? How will material use evolve under different development pathways and paradigms? What are these materials' environmental and societal impacts now and in the future,…
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Conceptualising and developing the practice of CLIL teachers
How do teachers conceptualise, develop and implement an effective CLIL practice?
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Operando research in electrochemistry
The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…
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Structured Parallel Programming for Monte Carlo Tree Search
The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.
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Electrocatalysis in Confinement: Metal-Organic Frameworks for Oxygen Reduction
The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.
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Algorithms for Analyzing Evolving Networks on the Dark Web & in Science
To answer questions that look beyond individual entities, network science studies the interactions taking place in complex systems. These complex systems can often have temporal information on when an interaction occurs.
- Science Coffee: Developing tools and practices to promote open and efficient science
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Electroreduction of nitrate and carbon dioxide on copper electrodes: a mechanistic study
In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…
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Take your next step!
Together we can make science open. Find the next step that fits your journey here.
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Westerdijk parking garage
Westerdijkgarage, Johanna Westerdijkpad 12, 2342DJ, Oegstgeest
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Programme structure
Through courses and research projects, you are trained by experts in the field.
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Access to remediation
When companies violate women’s human rights.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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Parallel Worlds
In this PhD project, we focus on improving the effectiveness and efficiency of LMs with narrative data.
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Catalysis of the electrochemical water oxidation to oxygen
Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Interactive visual retrieval of academic literature
The available tools for academic literature search return a list of ranked documents, which might not be ideal for some tasks. To facilitate these tasks, I am creating a visual representation of the academic search space where the user can browse academic topics.
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Aspects of the analysis of cell imagery: from shape to understanding
In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.
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Learning to look at LiDAR: combining CNN-based object detection and GIS for archaeological prospection in remotely-sensed data
The manual analysis of remotely-sensed data is a widespread practice in local and regional scale archaeological research, as well as heritage management.
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Dynamic Nuclear Polarization agents
Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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Model-assisted robust optimization for continuous black-box problems
Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.
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Resource allocation in networks via coalitional games
Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone
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Print referencing during e-storybook reading on a SMART board for kindergartners to promote early literacy skills
This study examined the effects of a classroom-focused intervention on different domains of early literacy. The intervention consisted of shared e-book reading combined with a print referencing technique done via a SMART board. The specific goal of the study was to examine whether children could be…
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Biotherapeutic Delivery
The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…
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Selective electrochemical H2O2 production by a molecular copper catalyst: A crucial relation between reaction rate and mass transport
Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
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Transcutaneous vaccination by means of coated and hollow microneedles
Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.
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Optimization of Patient Flow through EMT Facilities Applying Dynamic Behavioral Simulation Models
This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…
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Discovery, characterization and implementation of novel polyester depolymerizing enzymes
Plastics are an intrinsic part of our society. Annually, 400Mt of plastics are produced of which roughly 40% is discarded within a year.
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Knowledge Representation and Reasoning in Quantum System (KR2iQS)
Exploring the integration of AI and quantum computing, this study adapts Knowledge Representation and Reasoning (KRR) to enhance quantum circuit simulation and optimization.
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Learning From The Past: Making Software Greener and Faster By Mining Past Performance Data
Exploring the application of data-driven AI optimizations, this work leverages past software performance to reduce the carbon footprint and energy consumption of powerful computing applications.
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Portable Real-Time Audio Large Language Model System for Speech Disorder Therapy
This project aims to develop a portable, real-time intelligent system tailored for speech disorder therapy.
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Programme structure
The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.
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Research
Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.