The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Learning analytics tracks students’ online learning activities in order to support their learning. But what if most of their learning takes place offline, out of sight of digital eyes?

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In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

On 3 December 2019, Hanna Bosdriesz defended her thesis 'Furthering the fight against impunity in Latin America: the contributions of the Inter-American Court of Human Rights to domestic accountability processes'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. M.A.H. van…

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotores: G.W. Canters, T.J. Aartsma

CompaRe’s third virtual PhD roundtable was held on 29 March 2023. In attendance were the head of the centre, staff and PhD candidates. The roundtable focused on brainstorming a wide range of questions around the research process.

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This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Portraits of six Leiden professors for whom 8 February 2016 was the first time that they took part in the procession of Leiden professors at the Dies Natalis.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

An extra-long procession with musical accompaniment will mark the beginning of the university’s 450th birthday celebrations on 7 February.

How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

In this dissertation the author digs into the constituent elements of River Plate tango in order to decode how specific musical materials were organized and combined by four outstanding musicians: Pugliese, Salgán, Piazzolla and Beytelmann.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

Marius Staring, Associate Professor at the LUMC has been awarded the Chan Zuckerberg Initiative funding for further development of image processing software Elastix

As of 1 February 2009, PhD applications should no longer be sent to the International Office to be processed. The Graduate School will deal with its own applicants in future.

Computer scientist Bas van Stein conducted research at Tata Steel and BMW on how their production processes could be streamlined and optimised on the basis of data. As part of his research he developed some innovative products. PhD defence 20 September.

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

The research programme Probability Theory focuses on probability theory and on operations research.

With the aid of the General History of Africa (GHA) series of books, PhD candidate Larissa Schulte Nordholt researched what it meant to decolonise the history of Africa. This proved to be a tricky process, which was hampered by politics and lack of funding. PhD defence on 1 December.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: Prof. dr. I. Snellen, Co-Promotor: Dr. M. Kenworthy

At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…

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Promotor: H.V.J. Linnartz

Promotor: Prof.dr. H.L.V. Linnartz