Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and Latin America and the Caribbean together in mutually beneficial joint research projects that are content-driven, based on existing excellent research. Connecting research and researchers.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotores: H.A. Udo De Haes, P.M. Brakefield

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Overkleeft

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Addressing the core novel objective of scalably assessing the impact of possible interventions through counterfactual prediction based on spatio-temporal data.

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

The ‘Contagious!’ exhibition was set to open at Rijksmuseum Boerhaave in April but had to be postponed because of the corona crisis. The museum hasn’t been twiddling its thumbs in the meantime. The exhibition will now open on 16 July, and the corona crisis has a major role.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

New or improved treatments for chronic and acute illness.

A portrait of the complex historical process of over 500 years of European colonialism in the New World.

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

In this article, Dimiter Toshkov aims to explains the gender gap in COVID-19 vaccination attitudes.

How does invasive hybridization affect threatened native species?

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

From self-driving cars to innovative drug development: artificial intelligence (AI) will fundamentally change our lives in many different ways. We study this technology at a deep and fundamental level. And we seek answers to questions about liability and privacy, for example. Our researchers from…

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.