This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

Promotor: T. Schmidt

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Control of infectious diseases poses continuous challenges for human health.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

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This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

People already diagnosed with a mental disorder before the COVID-19 pandemic did not show a disproportionate increase in symptoms afterwards. This is one result from the first systematic review of longitudinal studies following their study population from before to during the first eighteen months of…

Together with researchers from over the world, the ENIGMA-Anxiety Working Group endeavors to unravel the neurobiology of anxiety disorders and related constructs.

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Autism spectrum disorders are more often diagnosed in boys than in girls. For Developmental Psychology professor Carolien Rieffe this raises the question whether autism remains undiscovered in girls and women.

On 9 November, Roosmarijn van Es defended the thesis 'The mind in the courtroom: on forensic mental health reports in judicial decision-making about guilt and sentencing in the Netherlands. The doctoral research was supervised by Jan de Keijser, Maarten Kunst and Janne van Doorn.

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

Everyone has been watching the attack on Ukraine, a war on the European continent, with a sense of foreboding. It will bring devastation, loss, suffering and worry and it raises questions. With these words, Rector Magnificus Hester Bijl opened the meeting on the war in Ukraine at Wijnhaven on Thursday…

Researchers from the LUMC and the Universities of Granada and Almería have found a gut bacterium that is associated with stronger muscles in people and mice. Their findings, published in the journal Gut, hint at the potential for new probiotics to support muscle strength and healthy ageing.

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

In this project we followed children of parents with an anxiety disorder. We wanted to examine how these children develop and try to better understand why it is that some children develop fears, whilst other children do not. In this project, we mainly focus on social anxiety disorder and panic disor…

The overarching aim of this theme is to increase our understanding of the mechanisms underlying altered cognitive, affective, and social behavior in relation to mental health problems.

Brave Little Ones is a research group that investigates the potential prevention of anxiety disorders in children aged 3-6 years old who are very shy or anxious.

Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom.

Can excessive worrying be reduced via stimulation of the vagus nerve?

A study into the impact of historical socioeconomic changes on the respiratory health of past Dutch populations (ca. 470-1850 CE)

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

Supervisor: Indira Nederpelt

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”