Discovery of metastasis promoting candidate drug targets

An overview of the research at the Cancer Dug Target Discovery group.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

Improving health, enhancing well-being and reducing health disparities across society.

Our language is adapted to the context in which we humans communicate. But computers ‘think’ differently. What would a language be like whose structure was optimally adjusted for use by humans and machines? Tessa Verhoef is trying to find the answer.

The red carpet treatment of expats, terrorism studies and women professors who took over the Senate Chamber. These are the best read articles of 2018.

Wouter Jong and Hanne Goossen explore best practices in risk and crisis communication within the tourism sector, aiming to identify effective strategies

More than 200 students completed their Bachelor’s degrees in combination with a three-year Honours programme last year. On 15 November, this resulted in a record number of certificates since the start of the Honours College 9 years ago. While listening to personal speeches, the students received their…

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Pathways of toxicity

Dutch astronomer Jorryt Matthee will receive the European MERAC Prize for Best Doctoral Thesis in observational astrophysics. Matthee received his doctorate at Leiden University in 2018 and is now doing research at ETH Zürich.

Dimiter Toshkov, Assistant Professor at the Institute of Public Administration, is a joint winner of the Haldane prize for best article published in 2013 in Public Administration - one of the oldest and most prestigious scientific journals in this academic field.

Last week Elsevier published the results of a survey among academy professors and teachers, asking what according to them was the best place to study in their profession. As for Mathematics, Leiden turned out to rank highest.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

PhD defence

English student Anna Carey has won the Student and City film competition. Her promotional film for Leiden as a student city was the best of the 12 entries.

A full overview of all loans and debts between banks would help preventing a new financial collapse. But banks do not provide this information. An econophysics model by Diego Garlaschelli and collaborators reconstructs the most probable situation and finishes first place in two independent tests.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Coordination chemistry is the chemistry of metal atoms

The Leiden Bio Science Park is nominated for Best Business Park in the Netherlands. The competition is set up by 'Bedrijventerrein Magazine'.

At the New Year’s reception of the Faculty of Science on 6 January, it was announced that Annelien Zweemer, Leiden Academic Centre for Drug Research, has been awarded the ‘Discoverer of the Year 2014’ prize. Matteo Brogi, Leiden Observatory, wrote the best dissertation in 2014 and Dennis Claessen, Institute…

From interview training and competence tests to internships and contact with alumni. At Leiden University there are many ways for our students to prepare for the job market, but the support available is often too fragmented and hard to find. How can we best prepare our students for a job market that…

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

Helping cancer patients with treatment choices.

Research from weekly magazine Elsevier shows that both the Leiden bachelor Wiskunde as the master Mathematics are rated as the best educational programs of the Netherlands according to professors. The first place was achieved by up to 70% of the votes.

During the Faculty of Science New Year's reception, Daniël Rozen was named Discoverer of the year 2015. Nienke van der Marel and Koen van der Maaden both won the prize for the best dissertation and Jeroen van Smeden was named Best Teacher of 2015.

Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…

The Dutch Michelle Sweering became the best math girl in the world at the International Mathematical Olympiad in South Africa. She is the only girl who won a golden medal.

Freek Janssen, a PhD-student in the department of Molecular Physiology, has received an award for the best oral presentation during the Young Medicinal Chemist Symposium organised by the European Federation of Medicinal Chemistry (EFMC-YMCS’16). Freek Janssen presented his work on “Development of Highly…

A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.

Research.com, a leading academic platform for researchers, has just released the 2023 Edition of Ranking of Best Scientists in the field of Law. Carsten Stahn Professor of International Criminal Law & Global Justice at the Grotius Centre for International Legal Studies in Leiden has ranked #340 in the…

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

During the opening of the academic year, true to tradition the LUC Teaching Prize will be awarded to the best lecture at the University. Get to know the nominees. This week: Christine Espin.

On 6 September 2021 Dr Vestert Borger, Assistant Professor of European law, was awarded the Best Book Prize by the University Association for Contemporary European Studies (UACES). Borger received the prize for his book 'The Currency of Solidarity: Constitutional Transformation during the Euro Crisi…

The University Association for Contemporary European Studies (UACES) has shortlisted ‘The Currency of Solidarity: Constitutional Transformation during the Euro Crisis’, written by Dr Vestert Borger, for its Best Book Prize.

On 11 January, the book chapter ‘Duty of care as a judicial review tool for SSM composite procedures’ written by Barbora Budinská and Jouke Tegelaar was awarded the 2023 Meijers Prize for best publication by a PhD candidate published in 2022–2023 in the research programme ‘The Progression of EU law’…

PhD defence

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

PhD defence

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Cell adhesion signaling

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