Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Green cities and a well-protected food system: Roy Remme and Oliver Taherzadeh study ways to achieve these. But how can their scientific findings lead to societal change? They share their experiences with science-policy initiatives.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Conference

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Education & outreach

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

The High-Tech Innovation specialisation consists of a 60 EC track alongside the students' core MSc programme: Astronomy, Chemistry, Computer Science, Mathematics and Physics.

Research training projects in the MCBIM group - Bachelor and master students of all chemistry related studies are more than welcome to take part in our research activities. We have various research projects, all in one way or another involving transition metal ions. Daily supervision in the laboratory…

With a MSc in Chemistry you are well prepared for a wide range of career opportunities. The chemical industry is one of the largest contributors to economic prosperity worldwide.

In the MSc Chemistry programme you will focus your studies on one of LIC's two main research areas, Chemistry for Health or Chemistry for Sustainability, and one specialisation.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

An attractive feature of the MSc Chemistry programme at Leiden University is the great flexibility of the study programme, allowing students to put together a tailor-made programme following their personal interests. Within the limits set by the programme, students can make their own choices and adjust…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Contact Biophysical Organic Chemistry/Solid State NMR

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

Few researchers see potential in research on glioblastoma, an incurable brain tumour. Alexander Kros brought together colleagues who are up to the challenge. European research funder ERC recently made 10.6 million euros available, a year earlier NWO provided 3 million euros. ‘In six years, we certainly…

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The government could do more to improve its diversity, says Saniye Çelik. By hiring people from a variety of backgrounds, the government will be better able to handle issues together with its citizens. Employees will also feel more connected to the organisation. PhD defence 10 November.

Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…

Contact Supramolecular & Biomaterials Chemistry

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid