A study into the impact of historical socioeconomic changes on the respiratory health of past Dutch populations (ca. 470-1850 CE)

We use laboratory animals to address research questions, but only when there is no alternative and the question cannot be answered in any other way. Read here why we conduct animals experiments.

Africa is rising and increasingly seen as a potential market by economic actors from Africa and the rest of the world. What is the interrelationship between governance, entrepreneurship and inclusive development?

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

-

On 3 April, Professor Syed Faisal Ahmed from the Leiden University Medical Center (LUMC) will give his inaugural lecture ‘Strength in Numbers’. He will emphasise the benefit of registries to rare disease research.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Heart failure is a major health care problem with high mortality.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.

This dissertation set out to provide both an integrated framework for the practices of teacher peer feedback and an in-depth understanding of teacher peer feedback in the Chinese vocational education context.

Nowadays children grow up with social media. This may influence the development of brain regions involved in social interaction. In their review article in Nature Communications, Crone and Konijn illustrate how neuroscience can contribute to a better understanding of how media and peers influence adolescents'…

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

What are ‘missing links’ in research on teacher professional development trajectories? We focus on the role and development of teacher facilitators in designing and implementing (collaborative) professional development trajectories.

Alireza Mashaghi from the Leiden Academic Centre for Drug Research (LACDR) will use state-of-the-art technology to investigate proteins that play a role in muscular dystrophy. His goal is to provide new insights for designing novel therapeutic strategies in the future. To accomplish this, Mashaghi receives…

Mapping of bacterial genomes to combat infectious diseases

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

The IBL has four Divisions: Animal Sciences, Plant Sciences, Microbial Sciences and Science Communication and Society.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.

-

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

Can subgroups of people be differentiated whose attitudes on the Sinterklaas festivities and Black Pete cluster with either a) high Dutch national identification or b) a strong preference for social hierarchy, also known as social dominance orientation (SDO; Pratto et al., 1994)?

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

Are you ready to tackle the most pressing sustainability challenges of our time? Do you want to contribute to a sustainable future while respecting the limits of our planet, but don't quite know how to do that yet? Our interdisciplinary Minor in Sustainable Development invites you to explore sustainability…

Ariane Briegel wants to use bacteria to detect cancer at an early stage. Together with postdoc Alise Muok, she is developing a method to quickly and cheaply test the urine of patients for the presence of suspicious molecules. They receive a grant of approximately 150,000 euros from the Dutch Cancer…

Cardiovascular disease is the leading cause of death worldwide.

-