569 search results for “lysosomal strong disorder” in the Public website
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Looking back at the Lorentz Workshop
“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”
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Hanna Swaab
Faculty of Social and Behavioural Sciences
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Presentations and Lectures
Members of our research team give different types of presentations and lectures.
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Strong investment in commercial fine particulate measuring device
Astronomers Professor Christoph Keller and Dr Frans Snik will be developing a commercial module for measuring fine particulates. They have been awarded an STW Demonstrator subsidy of 138,000 euros.
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Strong Leiden Representation at EUSA Conference in Miami
This year’s EUSA biannual research conference, which took place in Miami in May 2017, saw a large delegation of the Europa Institute Leiden leaving its mark. In several panels, Prof. Luuk van Middelaar, Dr. Moritz Jesse (Associate Professor at the Europa Institute), Dr. Armin Cuyvers (Assistant Professor…
- Literature
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Empathic or anxious mistakes?
Empathic or anxious mistakes? A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Clinical Neurodevelopmental Sciences Leiden University
The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.
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Some case studies of random walks in dynamic random environments
Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Computerised Dynamic Testing
An assessment approach that tailors to children’s instructional needs
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Our Research
From basic science to real-world interventions
- Martina Huber Lab - EPR Group
- Relevance
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The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…
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Mental health across the lifespan
This focus area adresses the mental well-being of people of all ages, from infants to the elderly. The emphasis lies on understanding, preventing, and treating mental health problems in a variety of contexts, such as the family, school, and work environment. We carry leading research and education programmes…
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Articles
Here you will find articles written by and about the Brave Little Ones research group.
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'Cleveringa’s protest teaches us the value of a strong community’
What can we learn from Cleveringa’s courageous protest speech? ‘Without imagination and a strong community, people do not stand up for one another,' says Cleveringa Professor Michael Ignatieff in his lecture on 26 November.
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‘All the members of the Young Academy Leiden have a strong sense of responsibility'
The Young Academy Leiden (YAL) acquired six new members on 1 September. We talked to the new and former chair of this platform for young academics about what they have achieved over the recent period and what is on the agenda for the coming year.
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Breakthrough by Leiden researchers in Pompe disease
Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.
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Publications
Electronic versions of our publications can be obtained by sending an e-mail to Esther van den Bos: bosejvanden@fsw.leidenuniv.nl
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New Methods for (f)MRI Analysis
Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.
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Migraine@Work: work ability in employees with migraine
This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?
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Research
Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.
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Fundamental research: Underlying mechanisms of disease and health
To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.
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New impulse for autism research in collaboration with China
Psychologists of Leiden University and Peking University will collaborate to investigate the deficiencies in emotion recognition in children with Autism Spectrum Disorder (ASD). The new collaboration fits very well in the policy of Leiden University in which intensified collaboration with China has…
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Cooperation is improving autism treatment
There are effective treatments for people with autism, says Wouter Staal, professor of Autism Spectrum Disorders, in his inaugural lecture on 4 May. However, it is not yet clear which treatment is most effective for which individual.
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Topologies and convergence structures on vector lattices of operators
This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.
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Social Anxiety and Normal Development
Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?
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Topic: Persistent physical symptoms
Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…
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People and Projects
Our team consists of the following members.
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Programme structure
The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the track-specific courses, the elective courses, a research internship and a thesis.
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BioTherapeutics
Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Our projects
Within Brave Little Ones, we work on several projects to support young children who are prone to anxiety or shyness. We focus on early identification of anxious behavior, as well as on supporting parents in how to respond to and manage this behavior.
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Brave Steps
A step-by-step approach to building confidence in anxiety-prone young children.
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Respiratory health and disease in the Netherlands
Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).
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Topic: Movement and mental functions
Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.
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Stimulating eye-contact in a virtual environment
Can a virtual character’s friendly non-verbal responses stimulate eye-contact in individuals with varying levels of social anxiety?
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Changing minds in social anxiety: A developmental network approach to neurocognitive bias modification
Which adolescents are more at risk of developing social anxiety disorder later in life?
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The SMILE study: Sleep Mood lntervention: Live Effectively a group intervention in students with sleep problems
Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?
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Topic: Novelty and enrichment
One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…
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Cool Little Kids
In the ‘Cool Little Kids’ research project, we investigate a parenting program that focuses on the prevention of the development of anxiety problems in young, anxiety-prone children.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers. However, there are far more graduates than vacancies, especially in mental health care, and competition is therefore fierc…
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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On the geometry of demixing: A study of lipid phase separation on curved surfaces
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
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Imperfections: using defects to program designer matter
Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.
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Hysterons and pathways in mechanical metamaterials
Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail.
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.