Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotor: Prof.dr. E. Deprettere

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

The role of mayors is changing from one where they are typically ‘security bosses’ within their own municipalities, to ‘super networkers’ who are increasingly engaged at regional and national levels. This is the opinion of Ruth Prins, programme director of the bachelor’s progamme in Security Studies…

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

On October 19, the Center for Law and Digital Technologies of Leiden University (eLaw) organized the first annual Hans Franken lecture. The lecture;

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

World history, connectivity and material culture, edited by Martin Pitts and Miguel John Versluys. From Cambridge University Press.

How do crises produce changes in specific European Union foreign policy areas, and how should we conceptualise these policy changes?

An important hormone excreting gland in the human body is the pituitary

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Optimality in plant properties and processing.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

All living systems are assembled from nature’s repertoire of small, medium, and large organic molecules. This theme focuses on the study, discovery and development of novel bioactive compounds obtained from biodiversity. We aim for new insights into the role of these molecules in the natural environment,…

The Game Research Lab uses digital games as a medium for academic research. It considers entertainment games and 'serious’ games as objects of study, develops novel approaches for creating, playing, and analysing games, and studies the interactions between games and AI.

The lyrical documentary about Leiden by American anthropologist Mark Neupert has become a hit. Leiden anthropologist Janine Prins taught Neupert the finer points of the subject in the course on Visual Methods offered by Anthropology. What does she think of Neupert's observation? ‘He's gone completely…

The master's specialisation in Visual Ethnography emphasises a strongly hands-on, empirical approach, which requires students to play an active role in mastering the audiovisual toolbox.

El X Congreso Internacional de la Asociación de Hispanistas del Benelux tendrá lugar en la Universidad de Leiden del 1 al 4 de noviembre de 2023. La conferencia será en modo presencial y se llevará a cabo en el edificio P.J Veth. El último día del congreso se llevará a cabo en la Haya.

Explaining the origins , patterns and outcomes of crisis management efforts.

New book on Dutch mayors governing local order and public safety.

A cautious response to a crisis or terrorist act avoids the creation of a culture of fear. This is another way to reduce our vulnerability to terrorism.

In their third year, students of International Studies get their teeth into difficult issues put forward by government and businesses such as Unilever and the World Food Programme. Students who take part gain valuable experience.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

A full overview of MCBIM PhD theses.

In the Research in Bio-Pharmaceutical Sciences specialisation you will perform research on various topics in the area of Drug Discovery and Development. The programme offers a high level of flexibility and can be tailored to your scientific interests. The major research project is hosted by the Leiden…

Bringing together scholars from Russia, the United States and Europe, this collection of essays is the first to explore the slippery phenomenon of post-Soviet nostalgia by studying it as a discursive practice serving a wide variety of ideological agendas.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.