Promotor: Prof.dr. J. Kuiper

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The aim of this project is to gain a better understanding of daily life, diet, mobility and health in late medieval Zeeland, as well as to test the potential of multi-isotopic analyses on a Dutch assemblage.

Have you got an old mobile phone lying around? If so, you can hand it in at Funky Phone in Lipsius. The phone will be recycled and you get to play an old-fashioned arcade game on the Funky Phone games computer built from discarded electronics. Vice-Rector Hester Bijl kicked off the Funky Phone Challenge…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

An inter-university conference will take place at the University of Namur, from 10-12 April 2024. Young researchers working on mobility & interactions in the Meuse-Rhine region between the ninth and fifteenth centuries are encouraged to submit abstracts of max. 500 words before November 1.

The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

A prisoner from Eindhoven who posted vlogs about his life in prison is attracting thousands of viewers on TikTok and other social media. Esther van Ginneken commented on regional news site ‘Omroep Brabant’: 'Contact is a human necessity.'

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

A more efficient solar panel sounds great. But what if these new panels consume more toxic materials, or their production consumes a lot of energy? Leiden environmental scientists, together with colleagues from the Fraunhofer ISE, address this multifaceted question in a new publication in the prestigious…

Peter Slort is the highly driven portfolio holder for Diversity with the Dutch National Police. Since November 2016 he has been spreading the importance of diversity throughout the police organisation.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

How did persistent social inequalities first emerge? What cultural trajectories and institutions made this key development possible? How can archaeological inform us about the formation of class societies?

In this project we think about the relationship between territory and contagion. Tracing the historical, political, and conceptual linkages between territorial bordering and migration on the one hand and disease related phenomena like contagion, immunity, and inoculation on the other, we ask how the…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotores: W. Jiskoot, F. Ossendorp

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

Leiden astronomers and ecologists are developing an instrument that lets people measure the quality of surface water with a smartphone.This international citizen science project, MONOCLE, is a collaboration between scientists and local people in Tanzania, Brazil and four European countries.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Heart failure is a major health care problem with high mortality.