Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

On 15 February 2024, Alexandros Sarris defended the thesis 'International Law and Governance of the Arctic in an Era of Climate Change'. The doctoral research was supervised by Nico Schrijver and Freya Baetens.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

The objective of the PhD Education and Supervision program is to educate PhD candidates in becoming professionals who are competent to conduct scientific research in the field of the pharmaceutical sciences independently.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Living together in a residential setting adds another dimension to this learning, as our students have to learn to live with others who may not share the same daily routines or standards.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

The Film Studio in Huizinga 0.13 has facilities to record professional videos for a range of educational and/or research purposes.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

This study examines the mutual intelligibility between all 225 pairs of 15 Chinese dialects, in two main branches, i.e., six Mandarin dialects and nine non-Mandarin (Southern) dialects.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotor: J.W.M. Frenken

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Ehrenfestgarage, Emmy Noetherweg , 2333BK, Leiden

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: J. Zaanen

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: Prof.dr. G.P. van Wezel

Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Are you eager to dive into a cutting-edge approach to innovation? Do you want to explore how frugality and frugal innovation can drive sustainability? And are you up for an international, real-life challenge? If so, this Leiden-Delft-Erasmus (LDE) minor on frugal innovation is for you!

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Heart failure is a major health care problem with high mortality.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

During the development of the Humanities Campus, as many 'green choices' as possibile are being made. This concerns the buildings as well as the surrounding area. Making the campus more sustainable is measured using the BREEAM.NL method.

Lecture

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Key publications of the Biotherapeutic Delivery group

Why do many medical institutions struggle to use AI in their clinical practice? What are the essential steps for and before an effective implementation of AI in radiology workflow? How can AI implementation trigger enduring improvements in the clinical process? The book shows how change management is…

Just as in phase 1, phase 2 of the Gorlaeus Building will focus on sustainable building.

Archaeological heritage management is concerned with the identification, protection, management and preservation of the material remains of human activity in the past (of whatever period and in whichever region of the world) and with the interaction that this involves with all kinds of stakeholders.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Promotor: G.P. van Wezel

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…