This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Dividing Worlds: Tsunamis, Seawalls, and Ontological Politics in Northeast Japan

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

In September 2021, ACPA PhD Candidate Gabriel Paiuk will premiere a new work titled Sound Theory (The Clouds) as part of the 2021 Gaudeamus Muziekweek Festival. The performance will take place on September 10th, 20:30 at the De Helling (Utrecht, NL).

Can epigenetic changes explain associations between early life stress and health outcomes?

Leiden Professor of Number Theory Manjul Bhargava has been awarded a Fields Medal, widely regarded as the Nobel Prize for Maths. Bhargava is a professor in Princeton, and since 2010 has also been the holder of the Stieltjes chair in Leiden.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Knowledge and culture subproject 3:

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

In this article, Jasmijn Boeken, explores in which ways the defining characteristics of the different zones can be found in the digital sphere.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

On Tuesday 15 September 2015, Bart de Smit has been appointed as professor of Algebra and Number Theory at the Mathematical Institute of Leiden University.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

The goal of this book is to place architectural studies, in which people’s interactions with each other and material resources are key, at the crossing of both landscape studies and material culture studies, where it belongs.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

What is the origin of educational ideas, e.g., the idea that intervention in infancy has long-lasting effects on development.

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

LCD screens use liquid crystals which have a high degree of order, even though they form a fluid. A new theory maps out the interplay between order, temperature and symmetry. Publication in Physical Review X.

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This dissertation provides crucial but as yet missing empirical data on the tone accent opposition in the so-called

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…