Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Drug development is hampered by the limited predictive value of conventional 2D culture systems, which fail to recapitulate the complexity of the disease microenvironment and contribute to high clinical attrition rates.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

How does invasive hybridization affect threatened native species?

One in two people will be diagnosed with cancer. World Cancer Day on 4 February raises awareness of the impact of this devastating disease. Leiden University is conducting various studies aimed at preventing and controlling cancer. Below are just a few examples.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

kiem grant: Investigating the anti-inflammatory potential of the PRG4 protein in preventing and alleviating rheumatoid arthritis

We investigate the processes underlying the patterns. We aim to explain biodiversity by investigating the distribution, function, development, and evolution of body forms, as well as physiological and behavioural variety among species. We collaborate with those specialized in describing, archiving,…

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Professor of Clinical Pharmacology Adam Cohen from Leiden University received the prestigious Dr. Saal van Zwanenberg Honorary Prize on 12 November. The prize honours a scientist who has distinguished themselves in the field of research that has directly or indirectly led to the development of new medicines…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Blended and hybrid teaching are presented as crucial in promoting teaching innovation, as well as more flexible study approaches allowing students to develop their own tailor-made study programmes. While the strategy document focuses on the positive aspects of digital teaching tools, no systematic study…

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

RARE-NL, a new collaboration between university hospitals, hopes to find treatments for rare diseases. Professor Teun van Gelder is representing the LUMC in the initiative.

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Book Presentation | Studium Generale Lecture

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Bert Fraussen, Assistant Professor at Leiden University, Adrià Albareda, a PhD candidate at Leiden University and Caelesta Braun, Associate Professor at Leiden University, identified combinations of consultation tools and analyzed their implications for stakeholder diversity.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder