Promotor: Prof.dr. E.F. Smets

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Getting personal

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

Chemists developed a new graphene-transferring method which makes use of cyclohexane. This new method leaves less impurities on graphene, is easier to handle than current methods and is widely applicable in graphene research. The publication will be on the cover of the journal ACS Central Science late…

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

-

The role of language in self-regulation and social behavior in children with an extra X chromosome

Students of the Faculty of Science have chosen Dennis Claessen (IBL) as the best teacher of last year.

This project aims at describing the Khoisan languages !Ora (Korana/Griqua) and !Ui of South Africa.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Maurijn van der Zee, evolutionary biologist at the IBL, received the National Zoology Award for his research on the evolutionary success of the insects. The award was handed out last Saturday, the 17th of December, by Professor Jan Kammenga, chairman of the Royal Dutch Zoological society.

Promotor: G.P. van Wezel

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Please note that the course Molecular Biology for Physics will start on Monday 5 February. Please check the schedules for the time and location!

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Lions in West and Central Africa form a unique group, only distantly related to lions in East and Southern Africa. Biologists at Leiden University confirm this in an article published in Scientific Reports.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Fourteen bachelor’s and master’s students are representing Leiden University in this year’s International Genetically Engineered Machine competition (iGEM). Their plan: to create a kit that can be used to quickly identify infectious diseases in case of an outbreak.

Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.

The application procedure is broken down into three parts.

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Promotores: A.H. Meijer, H.P. Spaink

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.