Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

The specialisation High-Tech Innovation is for MSc students in Sciences who are interested in interdisciplinary technologies and research related to /important for high technology industries, e.g. the semi-conductor industry or nano-fabrication.

Addressing Global Challenges through International Scientific Consortia

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

Research question

One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

How can we promote more durable solutions to protracted refugee situations and which roles can connectivity and mobility of displaced people play to improve protection and resilience?

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with the University of Havana.

To facilitate and accelerate a systemic change in society by creating a framework based on the current post-growth narratives, policies, and initiatives.

On Monday, 4 September the new bachelor programme Security Studies had its official start.

At Humanities, students are the point of focus. They are trained to be critical thinkers, academic professionals and involved citizens. Our lecturers and researchers encourage students to develop knowledge with which they can understand and indicate the major topics in our society. Because everything…

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

The first book ever on information-theoretically secure multiparty computation

On 28 June, Jakob Tobing defended the thesis 'The essence of the 1999-2002 constitutional reform in Indonesia: remaking the Negara Hukum. A socio-legal study'. The doctoral research was supervised by Jan Michiel Otto and Adriaan Bedner.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

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Promotor: Prof.dr. E.J.J. Groenen

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

This book offers novel perspectives on the national and international dimensions of the post-war welfare state in Western Europe and North America.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Joris Larik, Assistant Professor at Leiden University, wrote about the topics of the Brexit, the EU-UK Withdrawal Agreement, and Global Treaty (Re-)Negotiations.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Promotor: Prof.dr. G.P. van Wezel

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

This research develops and applies a new approach to study Aegyptiaca Romana from a bottom-up, Roman perspective.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

EU foreign policy has become increasingly politicised over the past years, amongst others as a consequence of the succession of crises. Crises may engender processes of crisis framing and contestation. This article focuses on how the policy demands being voiced in these processes of contestation are…

This book presents a thorough analysis of the Kurdistan Region of Iraq’s memory culture, focusing particularly on commemorations and representations of the Anfal and Halabja atrocities.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

Western thought has often dismissed shadows as fictional, but what if fictions reveal original truths?

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.