The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

The Leiden University Network for Health in Africa (LUNHA) aims to shift the focus of global health to be more about justice, fairness, and inclusion.

This article aims to provide a coherent foundation for empirical studies of interpersonal discussion on risk.

Global health governance is at a crossroads. As the world reckons with the existential threat of planetary crises (climate change, loss of biodiversity and pollution), international policy frameworks struggle to keep pace with a rapidly changing landscape in global health and public health.

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Heart failure is a major health care problem with high mortality.

WORLDING AMERICA researches how ‘play’ has been a key force in the past and present process of creating America as a coherent and hegemonic ‘world,’ from 1503 to the present.

On 8 February 2024 Leiden University celebrated its 449th anniversary.

Just published: Nederlands internationaal privaatrecht Special issue: Private international law and finance

How was FDR's image constructed—by himself and others—as such a powerful icon in American memory?

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

This dissertation studies the construction of Franklin Delano Roosevelt as a cultural icon in American memory, particularly by FDR himself.

This book considers the porous relationship between legality and illegality in Brazil, a country that presages political and societal changes in hitherto unprecedented dimensions.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

Promotor: Prof.dr. T. Schmidt

In this first ever podcast from LUCIS, hosts Yasmin Ismail & Sara Bolghiran explore what it means to imagine Muslim futures. Over 6 episodes we explore questions around what it means to imagine, the politics of imagination and what it would mean to engage with Muslims from the perspective of futures…

In 2024, many of our students and staff won great prizes and secured important research grants.

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Repairing organs, tissues and cells to fight chronic diseases.

An overview of the research at the Cancer Dug Target Discovery group.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Democracy in Action is a Horizon Europe-funded initiative exploring how grassroots movements, cultural spaces, and digital innovations can strengthen democratic participation. With a special focus on youth, women, ethnic minorities and night culture, we bring together researchers, grassroots movements,…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.