680 search results for “smit barrier re-pair” in the Public website
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Inverse problems for universal deformation rings of group representations
Promotor: P. Stevenhagen, Co-promotores: B. de Smit, F. Andreatta
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Understanding BRCA1(-complexes) in DNA repair and cancer
PhD defence
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Branching Out: The Clinical Relevance of Mismatch Repair Variants
PhD defence
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Control of replication associated DNA damage responses by Mismatch Repair
PhD defence
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Cleveringa Dallaire Critical Conversation Series
In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.
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Stress and trauma-related disorders
Our mission is to advance the understanding of mental health of individuals with a history of stress and/or trauma through rigorous interdisciplinary research, integrating insights from clinical psychology, neurobiology, and social sciences. We are committed to translating our findings into innovative…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Interventions
Our mission is to bring together research and practice focused on the improvement of mental health and the enhancement of treatment / psychotherapy success. To reach this goal we focus on the following paths:
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…
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Pieter ReitsmaFaculteit Geneeskunde
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Dissociative chemisorption on transition metal surfaces
The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…
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Anna van BuerenpleinAnna van Buerenplein 301, The Hague
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Computational approaches to dissociative chemisorption on metals: towards chemical accuracy
We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…
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Sex, Care & Robots
Sexuality is a fundamental part of being human. Yet, for many people with disabilities, it remains overlooked, unsupported, and surrounded by stigma. NWO-VIDI Sex, Care & Robots confronts that long-standing neglect with a project that envisions an urgent yet straightforward future: one in which sexual…
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Class invariants for tame Galois algebras
Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit
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Theoretical Chemistry
The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to characterize, and to accurately predict the outcome of chemical reactions at gas-solid and liquid-solid interfaces. Here the solid surface is typically a metal or an ice surface. These goals are important to many areas in…
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African languages archives
This collaborative research group (CRG) facilitates the synergies of researchers engaged with African languages and documentation of texts conducted in East Africa, paying particular attention to ‘endangered archives’ and ‘endangered languages’.
- Huizinga Lecture
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The Borders of Race in Colonial South Africa. The Kat River Settlement, 1829–1856
This monograph by Robert Ross provides a detailed narrative of the Kat River Settlement in the Eastern Cape of South Africa during the nineteenth century.
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Open Science Monitoring and Evaluation
Over the next two years, CWTS and Dialogic will develop a robust and context-specific monitoring and evaluation framework for Open Science in the Netherlands. This will be accompanied by the development of a prototype dashboard to showcase how such an Open Science monitor could be made visible.
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Towards Open and Reproducible Terrorism Studies: Current Trends and Next Steps
In recent years, the use of primary data in terrorism research has increased. In order to maximise the benefits of this trend, we want to encourage terrorism scholars to implement open science practices more systematically. This article therefore presents different avenues towards open and reproducible…
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UBC Europe – University-Business Cooperation in Europe
To goal of this project is to get a deeper, more comprehensive and up to date understanding of the state of University-Business Cooperations (UBC) in Europe, from the perspective of both the Higher Education Institutions and the business sector.
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Key publications
Key publications of the Analytical BioSciences and Metabolomics group
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Resumptive Prolepsis. A Study in Indirect A'-Dependencies
This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Chemical reactivity of O2, CO and CO2 on Cu surfaces
Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization
The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).
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Gorlaeus BuildingEinsteinweg 55, Leiden
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Making and creating with ages-old knowledge
The ability to create objects and structures with our hands has been essential to human development. This ability is something modern society is at risk of losing. Leiden archaeologists gather knowledge about ancient processes of ‘making and creating’ over the centuries, knowledge that helps our current…
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Contemporary International Criminal Law After Critique
In this article, the authors explore how international criminal law is moving into a ‘post-critical’ phase and examine its potential for emancipatory reform.
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Mobility
An estimated 17% of our university's total carbon footprint comes from the thousands of travel movements by our staff, students, visitors, and suppliers. Our aim is to reduce these emissions by a quarter in the coming years.
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Nostalgia for the Present
Ethnography and Photography in a Moroccan Berber Village
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Personal ornaments: changing identities in the Dutch Neolithic and Bronze Age
Numerous beads and pendants of amber, jet and bone have been found in Dutch Neolithic and Bronze Age context, both in settlements and in graves. Because ornaments are personal items, they are closely linked with people’s identity.
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Host-Microbe Interactions in Plant Sciences
Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…
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Drug Delivery to the Brain
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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Imaging the (un)imaginable of the Barrier Immune System
PhD defence
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Non-native EFL teachers’ intercultural identities: A comparison of China and the Netherlands
Students in EFL (English as a foreign language) classes may regard their non-native teachers as successful models of intercultural communication and mediators between the cultures of English-speaking countries (ES cultures) and their own cultures. Teachers who are aware of such roles may introduce and…
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The field and the classroom
The field and the classroom invites ethnographers to engage with critical and engaged pedagogies. Breaking down the barriers between fieldsite and lecture hall, this research cluster aims to interrogate the structures and values that shape anthropological and sociological education today.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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A timeless vale
Archaeological and related essays on the Jordan Valley in honour of Gerrit van der Kooij on the occasion of his sixty-fifth birthday
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Pulling the Brakes on Political Violence
Under what circumstances do paramilitary groups limit their use of political violence? This article examines the use of political violence by the PIRA.
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Living and dying on the Roman Frontier and beyond (LIMES XXV volume 3)
Proceedings of the 25th International Congress of Roman Frontier Studies 3
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Living (World) Heritage Cities
Opportunities, challenges, and future perspectives of people-centered approaches in dynamic historic urban landscapes
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Strategy and Structures along the Roman Frontier (LIMES XXV volume 2)
Proceedings of the 25th International Congress of Roman Frontier Studies 2
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Leiden University College The Hague
Leiden University College The Hague (LUC) offers a 3-year Bachelor's programme with a focus on Global Challenges: Peace & Justice, Sustainability, Diversity and Prosperity. The programme offers room for flexibility; you get to specialize in a major of your choice and combine this with a minor or electives.…