Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Cardiovascular disease is the leading cause of death worldwide.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Terrorism destabilizes governments, undermines civil society, threatens social and economic development, endangers democracy, and directly impacts human rights. The extraordinary events on 9/11 turned counterterrorism into a global governance project. The global collaboration is unprecedented with traditional…

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Observational, cognitive and physiological measurements in social contexts.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

In this doctoral dissertation (2012) the effects of the monetization of the Greek world in the 5th and 4th century on conceptions of reciprocity in friendship are analyzed.

Consensus and harmony or balance and reciprocity?

What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?

Promotor: H.V.J. Linnartz

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Several alumni, young alumni and students have been matched via the Leiden University Mentor Network.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: J. Schaye

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

On 22 February, Elody Hutten defended the thesis 'Tax Professionals Under Societal Pressure: A Dutch Case Study on Responses to BEPS'. The doctoral research was supervised by Henk Vording en Jan Vleggeert.

Research at the BPOC/SSNMR group is comprised of the following research themes:

Emotions play a key role in EU politics. This article examines how emotions influence the EU’s response to international crises and norm violations.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Lecture

Research carried out at Leiden University contributes to our knowledge of sustainability. This is essential if we want to work together to find solutions to pressing issues, such as the current climate emergency and the shortage of raw materials.

The 'living lab' Vrouwe Vennepolder is situated just north of Leiden, The Netherlands, and aims to find ways to improve the agriculture of the future.

Leiden University is committed to reducing our water consumption.

The Centre for Science and Technology Studies (CWTS) ensures that its research practices align with its commitment to inclusion, responsible evaluation, and open science. Our policies and guidelines provide clear principles for ethical research conduct, data management, sustainable travel, PhD supervision,…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

This project, under the supervision of Prof. Dr. Hans van der Plicht, comprises several studies aimed at the use of isotopes occurring naturally in organic material as tracers for both the climate change and its cultural impact at about 6200 BC. The research will be carried out by the co-applicant at…

Roll your sustainable sleeves! Our students and staff have found various ways to do just that, both at home and at our university.

The plans for making the University Library (UB) more sustainable will be carried out in three steps: first the glazing at the front of the building will be replaced with HR++ glass, then the skylights will be renewed and finally the air conditioning system will be updated. Once these steps have been…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…