Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

In this doctoral dissertation (2012) the effects of the monetization of the Greek world in the 5th and 4th century on conceptions of reciprocity in friendship are analyzed.

Consensus and harmony or balance and reciprocity?

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

This thesis describes the design, characterization and application of dextran based crosslinked network.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotor: H.V.J. Linnartz

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Cardiovascular disease is the leading cause of death worldwide.

Several alumni, young alumni and students have been matched via the Leiden University Mentor Network.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Towards Health and Resilience in Volatile Environments - People differ in how they are impacted by and respond to stressful experiences. Why is that?

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

How do different emotional expressions influence the behavior of other people in negotiations?

Yi Kyubo (1168–1241) was the foremost writer and poet of the Koryŏ dynasty (918–1392). Not Everything Unfolds as Anticipated is a miscellany of work from his Tongguk Yi Sangguk chip, a collection containing more than two thousand texts and considered the earliest substantial oeuvre of a Koryŏ writer…

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Lecture

Leiden University is committed to reducing our water consumption.

This project, under the supervision of Prof. Dr. Hans van der Plicht, comprises several studies aimed at the use of isotopes occurring naturally in organic material as tracers for both the climate change and its cultural impact at about 6200 BC. The research will be carried out by the co-applicant at…

Research carried out at Leiden University contributes to our knowledge of sustainability. This is essential if we want to work together to find solutions to pressing issues, such as the current climate emergency and the shortage of raw materials.

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

The 'living lab' Vrouwe Vennepolder is situated just north of Leiden, The Netherlands, and aims to find ways to improve the agriculture of the future.

The plans for making the University Library (UB) more sustainable will be carried out in three steps: first the glazing at the front of the building will be replaced with HR++ glass, then the skylights will be renewed and finally the air conditioning system will be updated. Once these steps have been…

The Centre for Science and Technology Studies (CWTS) ensures that its research practices align with its commitment to inclusion, responsible evaluation, and open science. Our policies and guidelines provide clear principles for ethical research conduct, data management, sustainable travel, PhD supervision,…

Roll your sustainable sleeves! Our students and staff have found various ways to do just that, both at home and at our university.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

On 5 September 2017, Alessandro Tonutti defended his PhD dissertation

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.