Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Research at Leiden Observatory spans the full width of modern astrophysical enquiry. It is based on observation, theory, simulation, and experiment. Two broad clusters characterize the ongoing research. Within each theme, researchers carry out their personal and specialized research programme. The two…

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

On Thursday 21 November 2024 Jake Benson successfully defended a doctoral thesis and graduated.

Due to the almost complete disappearance of the archive of the Old Dutch West India Company (WIC, 1621-1674) not much is known about the ships and crews of this company. In this project we start the reconstruction of this basic information making use of new digital humanities techniques to extract this…

This projects investigates spatial relations between soils and other resources and the urban layout of a classic Maya center in Campeche, Mexico.

The Routledge Handbook of Contemporary Vietnam is a comprehensive resource exploring social, political, economic, and cultural aspects of Vietnam, one of contemporary Asia’s most dynamic but least understood countries.

On the 27th of February, Marta Morgado successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Marta on this achievement!

Responsible AI for science and a strong and resilient society.

Using a corpus of textual, literary, and other evidence to shed new light on the age at which medieval women gave birth.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

In our HANDS!Lab for Sign Languages and Deaf Studies, we run projects pertaining to sign language linguistics with a focus on Africa. In addition, we are running projects on sign language teaching, tactile signing, deaf people’s experiences with the legal system, and deaf history.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

We always have several ongoing studies running in our labs. Below you can find information about each one.

Promotor: K.H. Kuijken

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Promotor: M.A.G.J. Orrit

In the contemporary myriad of definitions and approaches of landscape, the starting points and limits of the concept of landscape biography are being explored, but also tested in this thesis. What exactly is a landscape biography? What does it constitute of? Is landscape biography just a narration of…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2017.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.

In this thesis, both the obscured and unobscured star formation of high-redshift galaxies (UV-bright galaxies and serendipitously identified [CII]-emitters) is investigated.

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

Knowledge and culture subproject 4:

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…

Ancient historians have long been aware that patterns of coin circulation can shed light on levels of economic integration in the Roman Empire. More than forty years ago, Hopkins argued that large amounts of tax money were spent in the frontier provinces and that the non-military provinces recouped…

On December 18th, Viktorija Kostadinova succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Viktorija on this great result.

The imaging group focuses on bio-imaging, image analysis and visualization.

Collecting data in sports increased in importance the last few years.

The Impact of Mobility and Migration in the Roman Empire assembles a series of papers on key themes in the study of Roman mobility and migration.

Although it is often assumed that the stereochemistry in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, experimental and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported.

The specific interest of this project is to explore the links between international financial levers and higher education, research and innovation systems in the Sahelian region.

Amerindian intra- and inter-insular relationships and social organization in the pre-colonial Windward Islands.

Extensive research is being conducted at the Institute of Criminal Law and Criminology on developments in sentencing and punitive measures and how judges and other actors in the criminal justice system reach decisions. Another focus area is how punishments and measures are implemented and the effect…

PhD Research Projects:

In what way can teachers support and enlarge student engagement in a blended learning context?

Five talks will be given during the Leiden Science Family Day: two children's lectures and three lectures for adults. Will you be there ?