Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

This study helped to identify and summarize how value-based healthcare (VBHC) is conceptualized in the literature and implemented in hospitals. Furthermore, an overview was created of the effects of both the implementation of VBHC and the implementation strategies used.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

LED3 is the combined effort of four excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the institutes.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

What are the functions of the endocannabinoid system?

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Mapping of bacterial genomes to combat infectious diseases

Comparing individual health data with group data allows doctors to give personalised advice and patients to learn from one another's experiences. Wessel Kraaij, Professor of Applied Data Analytics, shows how personal data can have a valuable predictive function. Inaugural lecture 24 February.

‘Our health is the area that stands to gain most from artificial intelligence.’ The three universities in Zuid-Holland are helping make these gains. Three researchers talk about their collaborative research into AI for health, drug discovery and healthcare in the AI knowledge cluster in Zuid-Holland.…

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

PhD defence

A dental anthropological approach to foodways, health and disease, and crafting in the pre-Columbian Caribbean.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

In this master programme you learn interdisciplinary approaches to address scientific and societal challenges in the field of (bio)medical sciences. The research in our programme Biomedical Sciences relates to the maintenance of health and prevention of disease. You will acquire a skill set suitable…

Evidence and Care-work in a home visiting program to promote maternal sensitivity and parental reflective functioning in Alexandra township, Johannesburg, South Africa.

A new health programme will reward patients with - or at risk of developing - cardio-vascular diseases for keeping to a healthy lifestyle. A research group including psychologist Andrea Evers has been awarded 2.5 million euros by the Dutch Heart Foundation and the Ministry of Public Health, Welfare…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The major aim of the Health and Medical Psychology specialisation is to provide you with the theoretical background and professional skills required for health and medical psychology research and interventions. Health and Medical Psychology looks at how health, illness, and recovery are affected…

While the U.S. reconsiders its global commitments, Japan remains a stable partner, having cultivated the roots of its bilateral partnerships in the Indo-Pacific region and expanded its commitment to global health.

RARE-NL, a new collaboration between university hospitals, hopes to find treatments for rare diseases. Professor Teun van Gelder is representing the LUMC in the initiative.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

Which plant leaf characteristics are involved in thrips resistance in tomato?

Nederlanders met lage inkomens lopen tot 1,5 keer meer risico op het krijgen van een hartaanval of beroerte dan rijkere landgenoten. Bij Surinaamse Hindoestanen is dit risico 1,9 keer hoger. Dat blijkt uit onderzoek van het LUMC en het HagaZiekenhuis. Nederlandse artsen kijken tot nu toe niet naar deze…

Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Tobacco use in the Netherlands is no longer declining and is instead increasing, raising concerns among public health experts and policymakers. In particular, the rapid rise of vaping among young people, as well as the growing presence of illicit products, is drawing attention.