The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

An overview of research themes and projects at ABS.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

An international team from the Netherlands, France, Norway and Austria demonstrate how new sequencing technologies can be used to efficiently generate the genome, DNA, sequence of an endangered animal, the European Eel.

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…

Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.

An overview of the research at the Cancer Dug Target Discovery group.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

Are you looking for a research project?

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

On 7 February, the first co-creation event of the Expanding (Event) Horizons project took place at Leiden University. Nearly 30 educators, scientists and consultants from diverse backgrounds designed inclusive projects for engaging students from underrepresented minority groups with educational Science…

Jingxian Wang, PhD at ICLON, examined technology integration in primary and secondary education. Defence on 6 July.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

On April 26, three separate projects from LIACS Media Technology group members were awarded a

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Our annual "Science to Experience" exhibition of student works is hosted by the V2_ Lab for the Unstable Media. This year's theme is "TIME".

On February 24 2022, the Technology group organized a GTGC Tech Talk. During this meeting Anna-Lena presented her first PhD paper "Bringing the Social Back in: Big Science Collaborations as Social Spaces of Strategic Action".

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

On Wednesday the 1st of December, the thematic area on technology of GTGC organized its first research seminar, by Anna-Lena Rüland and Babak Rezaeedaryakenari. James Shires, together with his colleague Max Smeets at ETH Zurich, presented on their project "Cyberspace and (In)stability: The Structural…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotores: W. Jiskoot, F. Ossendorp

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

Developing safer alternatives to harmful PFAS filters and seeking new enzymes for medical applications. Two projects with Leiden researchers have been awarded funding through the Dutch Research Council's (NWO) Open Technology programme.

Our annual "Science to Experience" exhibition of student works is hosted by the V2_ Lab for the Unstable Media. This year's theme is "LIVING".

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Physicians and researchers of the Leiden University Medical Center (LUMC) and Leiden University are working on therapies for restoring damaged organs such as hearts and kidneys. They are even trying to construct tailor-made organs. Read more on this topic in the new science dossier on Vascular and Regenerative…