1,496 search results for “research with animal” in the Public website
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Pursuing Whiteness in the Colonies: Private Memories from the Congo Freestate and German East Africa (1884–1914)
Pursuing Whiteness in the Colonies offers a new comprehension of colonial history from below by taking remnants of individual agencies from a whiteness studies perspective. It highlights the experiences and perceptions of colonisers and how they portrayed and re-interpreted their identities in Afric…
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Before Temples
A study on the utilisation of Iron Age rectangular structures and related depositional practices in the Low Countries
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Lab facilities Social and Organisational Psychology
Observational, cognitive and physiological measurements in social contexts.
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Targeting lipid metabolism to develop host-directed therapeutics for mycobacterial infections
Our research aims to develop drugs that boost the host immune response to better defend us against mycobacteria.
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Biophysical feedbacks between seagrasses and hydrodynamics in relation to grazing, water quality and spatial heterogeneity
Consequences for sediment stability and seston trapping
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The Prehistory of Asia Minor
From Complex Hunter-Gatherers to Early Urban Societies
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CurveBend
CurveBend project aims to study the restauration of biodiversity in livestock landscapes through collective action, practical solutions, and research on ecological knowledge co-creation.
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On the efficacy of digitized storybooks for young learners with attention problems
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Lost in translation: The toll-like receptor 7 induced pharmacological challenge model of the skin
This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.
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Simple rule learning is not simple: Studies on infant and adult pattern perception and production
On December 11th, Andreea Geambasu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Andreea on this great result.
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Alexandria the Cosmopolis
A global perspective
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Segments and rules: a comparative study into the computational mechanisms underlying language acquisition
In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…
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Figurations animalières à travers les textes et l’image en Europe
Fish climbing trees, storks taking care of their parents… Premodern textual and visual culture presents us with a fabulous bestiary that reveals ingenious and rich reflections on the animal kingdom.
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Putting dental calculus under the microscope
Doctoral Thesis
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Welfare and Inequality in Marketizing East Asia
Provides a cutting-edge comparative political economy analysis of welfare and inequality across ten East Asian countries.
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
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Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Apocalypse, empire, and universal mission at the end of antiquity: world religions at the crossroads
On Tuesday 10 September 2024 May Shaddel Basir successfully defended a doctoral thesis and graduated.
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Farmers of the Coast
Archaeological research of coastal farming communities on the southern North Sea coast, 2000-800 BC
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Clock disruption in diurnal versus nocturnal migrating fish
Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Orchid mycorrhizal interactions: evolutionary trajectories and ecological variations
The mycorrhizal symbiosis is among the most widespread species interactions on Earth. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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In vitro and in vivo evaluation of synergistic and opposing effects of Chinese herbal medicine and natural compounds on immuno-modulation.
Can we link multiple components from herbal extracts with their biological activities?
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Lab facilities Comparative Psychology and Affective Neuroscience
We study expressions of emotion and social decision making across species.
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Küçük Asya'nın Tarihönces
Karmaşık Avcı-Toplayıcılardan Erken Kentsel Toplumlara
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Key innate immune components controlling intracellular infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Emblems and the Natural World
The multiple connections between emblematics and Natural History in the broader perspective of their underlying artistic, literary, political and religious ideologies.
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Social Anxiety and Specific Phobia in youth
Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!
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The "characterization" of Japan: From Merchandising to Identity
Ruobin Han defended her thesis on 21 March 2017
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The Western European Loess Belt
Agrian History, 5300 BC - AD 1000; C.C. Bakels
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Outreach
We recognize the importance of communicating about our scientic work to the general public and we enjoy doing so. Recently, we received funding from the Pilot fund Science communication by scientists: Appreciated! (with members of Change Leiden) to engage children and adolescents in science communication…
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MycobacteriumXL: The intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Home Ecologics – Dutch multispecies homes
How do humans, non-humans and their interactions and relations shape the home as ecological and social space?
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The effects of burying beetle social behaviours on interspecific interactions
This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.
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Education
Our education programmes span the entire spectrum of Animal Sciences, Evolution, Biodiversity and Conservation, Microbial Biotechnology and Plant Sciences.
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The research-teaching nexus in the humanities: Variations among academics
Central in this thesis are the various forms the research-teaching nexus can take in the university, especially in the Faculty of Humanities. The importance of a strong relation between research and teaching is advocated by many academics, but debate is going on about the forms this strenghthened relation…