How public service motivation and professionalism affect decision-making in dilemma situations. Individuals who work in the public sector see themselves confronted with conflicting values, contradictory demands, and the need to serve an at times difficult to define ‘public interest’.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Planets are formed in disks of gas and dust around young stars.

On the 23rd of January, Anastasiia Ionova successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Anastasiia on this achievement.

This article presents the findings of an explanatory study into the perceptions of Dutch Muslims in The Hague concerning pre-emptive counter-extremism and de-radicalisation policies.

Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

In this thesis, we present new laboratory data of interstellar dust analogues.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Many galaxy clusters exhibit bright diffuse radio emission that traces the underlying structure of the intracluster medium (ICM).

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: T.H. Oosterkamp

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

In this chapter of the Elgar Encyclopedia of International Relations, Carraro explores how expertise is defined and contested in International Relations.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

The integrity and reliability of academic research are of fundamental importance to the university.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

On 25 May, Roxane de Massol de Rebetz defended the thesis 'Beyond the dichotomy between migrant smuggling and human trafficking: a Belgian case study on the governance of migrants in transit'. The doctoral research was supervised by Maartje van der Woude, Joanne van der Leun and Masja van Meeteren.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

Scientists, including our faculty colleague Dr. Mike Field, studying an exceptionally well-preserved woolly rhinoceros have revealed details of what Britain's environment was like 42,000 years ago. The beast's remains were discovered in Staffordshire in 2002, buried alongside other preserved organisms…

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

How can the Indonesian National Ombudsman make the transition from autonomous to responsive justice in view of the day-to-day challenges it is faced with?

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

On Tuesday 17 October 2017 Alexandre Genest defended his PhD dissertation ‘Performance Requirement Prohibitions in International Investment Law’ as part of a double PhD programme at the Universities of Leiden and Ottawa. The Supervisors are Professors M.E. Koppenol-Laforce. F. Baetens (Universities…

In this article in International Affairs, Saskia Postema and Jan Melissen examine Chinese celebrities' UN-affiliated Weibo activism in the context of China's increasing engagement in the United Nations, which coincides with a shrinking domestic public sphere under Xi Jinping's leadership.

My research addresses the function of the much-debated particle -nā in Biblical Hebrew, often translated with “please”, from the point of view of the most important ancient Bible translations (Greek, Syriac, Latin). It combines textual criticism, translation technique, discourse pragmatics, and the…

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

This minor equips students from diverse disciplines with the knowledge and skills to critically engage with and strengthen Africa’s role in a globalised world through integrated and sustainable approaches. It builds on the ambitions of the African Union’s Agenda 2063 and the United Nations’ Agenda 2030,…