Promotores: J. Jonkers, K.E. de Visser

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Promotor: Roeland M.H. Merks

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

List of Support Departments at LION and the Faculty of Science

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

These awards honour researchers who turn scientific insight into real-world impact. From master’s students to postdocs, they highlight exceptional work in life sciences, health sciences, biotech, or environmental health sciences with data science at the core. Meet the 2025 winners.

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

This paper provides an initial answer to the question regarding eco-labels: ‘How can we make the development of eco-labels more structured and transparent?’

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

This book explores the fascinating microvariation in Bantu languages and proposes a new syntactic analysis of subject and object agreement crosslinguistically. This book is open access!

This collection of seventeen essays takes its inspiration from the scholarly achievements of the Dutch historian Jan Lucassen. They reflect a central theme in his research: the history of labor.

Do recent developments in the European security architecture signal the end of multilateral cooperation, or the beginning of a new era with emerging forms of international security collaboration?

This thesis presents a detailed description of the phonology, the tone system and the grammar of Liko, a Bantu language spoken by about 70,000 people in the northeastern part of the Democratic Republic of the Congo. It provides numerous examples.

Abrupt Climate Change and Cultural Transformation

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

The central inquiry of this thesis revolves around how ontology can adequately accommodate the existence of necessary physical relations. Initially, the thesis demonstrates the imperative acknowledgment of necessary physical relations by showcasing the failure of Neo-Humean theories.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

Patterned detectors are an existing technology that can be found in almost all color cameras.

Paisaje, cerámicas e interacciones

Mr. Ade Jaya Suryani defended his thesis on 28 January 2021

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

In this article, Madeleine O. Hosli and Wen Pan examine how intergovernmental dynamics shaped the European Stability Mechanism, using Liberal Intergovernmentalism to assess negotiation phases, the influence of major member states, and which theoretical assumptions hold or need qualification.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

On the 29th of June, Martin Kohlberger successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Martin on this achievement!

The Mathematics and Algebra, Geometry and Number Theory specialisation programme consists of 120 European Credit Transfer System (EC) points and includes a research project (40 EC), advanced courses (min 60 EC) and electives (maximum 20 EC). 30 EC are to be taken from the Dutch national Mastermath p…

This dissertation focuses on teacher professional learning and collaboration in secondary schools.

Accurately recognising others’ emotions is a fundamental social skill, relevant for navigating the social world from early childhood. Children’s ability to do represents a milestone in their socioemotional development and is associated with a number of important psychosocial outcomes. Many individual…

Promotor: Prof.dr. F. den Hollander

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

This book presents a comprehensive description of the grammar of Logba, one of the fourteen Ghana-Togo Mountain (GTM) languages spoken by approximately 7,500 speakers on the South-Eastern frontier of the Ghana-Togo border. It is the outcome of fifteen months research in Logba speaking communities.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The Applied Mathematics Programme consists of 120 European Credit Transfer System (EC) points. The programme consists of advanced courses (min 60 EC), a research project (40 EC) and electives (max 20 EC).

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Summary

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.