This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Climate change is made up, the secret services murdered Pim Fortuyn and JFK, and the moon landing was a fake show. Conspiracy theories are of all times, providing sensation and entertainment, but also unrest and fear. The corona pandemic is new fuel for conspiracy theorists who set fire to 5G masts,…

A new bill is currently under debate in the Netherlands, advocating raising the prison sentence for manslaughter from 15 to 25 years. ‘This very serious crime (...) evokes feelings of disgust and insecurity in society’, Dutch Minister for Justice and Security Grapperhaus comments on the sentence that…

The League of European Research Universities (LERU) makes recommendations for the future of the Social Sciences and Humanities research in Europe. Social Sciences and Humanities (SSH) research is vital to build an innovative and resilient Europe.

How do people vote? How rational are voting choices? How much do external factor weigh in? In this article social scientis provide some background.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Leiden University offers its students a wide range of bachelor's, master's and minors that explore sustainability or climate. Here, you find an overview of those programmes in the academic year 2020-2021.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Delineating psychophysiological endophenotypes of social anxiety disorder

Contact Supramolecular & Biomaterials Chemistry

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Contact Theoretical Chemistry

Promotor: E. Bouwman Co-Promotor: S. Bonnet

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

On 12 November, Clare Fenwick defended her doctoral thesis, The Political Economy of Immigration and Welfare State Reform: A Collection of Comparative Political and Economic Essays on Human Mobility and Social Protection. The PhD research was supervised by Olaf van Vliet and Kees Goudswaard.

Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Have you ever experienced the feeling of awkwardness when attending a party where you didn’t know anybody? Ever felt shy at a party within the first few minutes? While this feeling is labelled loosely as feeling socially anxious, social anxiety disorder goes to a much further extent.

Coordination chemistry is the chemistry of metal atoms

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

The master’s specialisation Bio-Pharmaceutical Sciences and Education at Leiden University combines fundamental chemistry research with an excellent education in becoming a Chemistry teacher.

As part Leiden University's interdisciplinary programme Social Resilience and Security, dr. Marieke Liem has been appointed Professor Security and Interventions effective 1 January 2020.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Curved single crystals provide variable, but well-defined surface structures.

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

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