This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Promotor: Prof.dr. J. Kuiper

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Promotor: J. Kuiper

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

Promotores:Th.J.C. van Berkel, M. van Eck

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This interdisciplinary minor addresses sustainabilty challenges from a systems perspective, and investigates ways to sustain society within planetary boundaries.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Let op: bachelorstudenten van de Faculteit der Rechtsgeleerdheid kunnen vakken uit het eigen curriculum niet opvoeren voor deze minor. Je kunt alleen de gebonden keuzevakken volgen en opvoeren die geen onderdeel uitmaken van je eigen bachelorprogramma.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Zonder een gewas opnieuw te zaaien toch nakomelingen produceren, die zelfs groter kunnen zijn dan de ouderplant. Volgens Leidse onderzoekers is dat mogelijk door het overstimuleren van één gen. Daarmee verjongt een cel en gaat deze terug naar de embryonale fase.

Wil je weten welke invloed opvoeding binnen en buiten het gezin heeft op de ontwikkeling van het kind? Kies dan deze specialisatie!

Oogst na oogst binnenhalen van rijstveld, zonder nieuwe rijstplanten te zetten? Door een ontdekking komt dit scenario misschien wel dichterbij. Leidse wetenschappers hebben een gen ontdekt waarmee ze eenjarige planten na het bloeien opnieuw laten groeien, in plaats van dat de planten sterven. Publicatie…

Leidse biologen hebben aangetoond dat een gen dat aanwezig is in planten, dieren en gisten wel degelijk een belangrijke rol speelt in planten, al werd daar jaren anders over gedacht. Zonder het gen blijkt de ontwikkeling van vaatweefsel in planten niet goed op gang te komen. Publicatie in Nature Plants…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

In onze eenjarige masteropleiding leer je hoe je het dagelijks leven van kwetsbare groepen - zowel in Nederland als wereldwijd - kunt bestuderen, en hoe je ze binnen de complexe processen van sociale en globale ontwikkeling kunt plaatsen.

Het volgende rapport bespreekt onze enquête over de UN Sustainable Development Goals die werd verspreid onder onderzoekers aan de Universiteit Leiden in november 2021.

Kom naar onze online en oncampus events om ons beter te leren kennen!

The Advanced Master's specialization Peace, Justice and Development at Leiden University examines the legislation that governs international relations in an increasingly complex, interdependent global society. The study covers a wide range of legal disciplines like criminal law, human rights law, investment…

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Lees meer over de informatieve activiteiten voor de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden – zoals webinars, online open dagen, virtuele rondleidingen en Master Talks-video’s.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Promotie

Ontwikkel je onderwijsvaardigheden samen met docenten van andere Nederlandse universiteiten.

Bekijk het studieprogramma van de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden: semesterindeling, studiepunten, kern- en keuzevakken.

Neem contact op voor vragen over de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden, zoals over de opleiding zelf of ondersteuning via het Admissions Office.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.