187 zoekresultaten voor “cancer” in de Publieke website
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Tumoren trekken bloedvaten aan met ‘afstandsbediening’
Onderzoekers van de Universiteit Leiden hebben aangetoond dat tumoren op een mechanische manier bloedvaten kunnen aantrekken, waardoor ze kunnen groeien. Het team publiceerde deze ontdekking op 2 maart in Nature Scientific Reports.
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EGFR inhibitors in colorectal cancer
Promotie
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Ruim 700.000 euro voor de strijd tegen agressieve borstkanker
Eiwitten remmen die een rol spelen bij de groei van agressieve kankercellen, dat is het plan van professor Bob van de Water en zijn team. Zij ontvangen hiervoor ruim 700.000 euro van KWF Kankerbestrijding. Onderzoeker Maaike Vreeswijk en patholoog Danielle Cohen zijn aangesloten vanuit het LUMC.
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Targeting SUMO Signaling to Wrestle Cancer
Promotie
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The path to individualised breast cancer screening
Promotie
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Raman Spectroscopy in Bladder Cancer Diagnosis
Promotie
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Monitoring Outcomes In Colorectal Cancer Surgery
Promotie
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Glycoproteomics assays for prostate cancer biomarker discovery
Promotie
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Identification of regulators of cancer - immune interactions
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Dissecting the immune microenvironment of breast cancer
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Lateral Lymph Nodes in Rectal Cancer
Promotie
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Formulation of Peptide-Based Cancer Vaccines
Promotie
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Tailored treatment for colon and rectal cancer
Promotie
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Immuunsysteem speelt dubbele rol bij borstkanker
Het immuunsysteem speelt een paradoxale rol bij de uitzaaiing van borstkanker. Dat ontdekte Kelly Kersten in haar promotieonderzoek. Sommige immuuncellen dragen bij aan uitzaaiingen, terwijl andere cellen kunnen worden aangezet om chemotherapie effectiever te maken. Promotie op 7 februari.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Leukemia treatment & cognitive development
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Immuno-photodynamic therapy of cancer
Promotie
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Experimental optical imaging during pancreatic cancer interventions
Promotie
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Optimizing clinical management of T1 colorectal cancer
Promotie
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Harnessing neoantigens for targeted cancer treatment
Promotie
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Genetic and lifestyle factors in breast cancer prognostication
Promotie
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Prediction of contralateral breast cancer - Statistical aspects and performance assessment
Promotie
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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NL-BioImaging AM
NL-BioImaging AM is een onderzoeksinfrastructuur gericht op het bevorderen van vooruitgang in de meest geavanceerde microscopietechnologieën en het bieden van open toegang tot deze technologieën aan een brede gemeenschap van academische en industriële gebruikers. Alle Nederlandse bio(medische) microscopie…
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Unraveling mucin type o-glycosylation signatures of colorectal cancer
Promotie
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Characterization of candidate genes in unexplained polyposis and colorectal cancer
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
Promotie
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The tumor-stroma ratio in epithelial cancer types
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Early Detection of Pancreatic Cancer in High-Risk Individuals
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Towards personalized treatment for high risk endometrial cancer
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Quality assessment and multi modalty in gastric cancer treatment
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Understanding the complexity of TGF-beta signaling in cancer
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Refining individualized treatment in older patients with breast cancer
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Diagnostic challenges of today's lung cancer pathology
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
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Optimizing immunotherapy in locoregional and metastatic urothelial cancer
Promotie
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Nieuwe hoogleraar wil betere zorg door app voor sarcoompatiënten
Artsen moeten samen met patiënten met bot- en wekedelentumoren op zoek naar een optimale persoonlijke behandelstrategie, vindt prof. dr. Michiel van de Sande. Hij heeft een app ontwikkeld die bij de behandelkeuze ondersteunt. Van de Sande is vanaf 1 mei 2020 benoemd tot Leidse hoogleraar Orthopedie,…