Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Hoe heeft migratie de Ierse en Italiaanse samenleving sinds 1945 beïnvloed?

Professor Dirk Vandewalle is een internationaal veelgevraagde en gerenommeerde Libië-expert. In deze lezing gaat hij in op twee essentiële vragen over de huidige situatie in Libië. Hoe komt het dat het Libische politieke systeem zo fragiel geworden is? En hoeveel hoop is er nog dat Libië als eenheid…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

The Role and Effectiveness of the G20. In dit artikel, gepubliceerd in The Changing Global Order onderdeel van the United Nations University Series on Regionalism book series, bespreekt auteur Jaroslaw Kantorowicz de evolutie van de G20.

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

EUMOTIONS onderzoekt welke rol emoties van politieke elites (op EU- en lidstaatniveau) spelen in het formuleren van beleidsmogelijkheden van de EU tijdens internationale crises.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

In dit artikel wordt betoogd dat de weerstand tegen groene overheidsinvesteringen afhankelijk is van de wijze van financiering.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Alessandro Tonutti heeft op 5 september 2017 zijn proefschrift:

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Academici hebben op het gebied van inlichtingen geworsteld met de vraag onder welke voorwaarden internationale samenwerking op het gebied van inlichtingen plaatsvindt. De meeste richten zich op transactionele motieven en gegarandeerde opbrengsten, de zogenaamde ‘Quid pro Quo’. Tegelijkertijd wordt vertrouwen…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Dit proefschrift richt zich op de opvattingen en percepties van Chinese en Nederlandse docenten over de rol van onderzoek in het hoger onderwijs.

Het doel van dit proefschrift was om mogelijke risicofactoren voor overgewicht in de vroege kindertijd te ontdekken die als basis kunnen worden gebruikt voor het ontwikkelen van opvoedinterventies voor het verminderen van overgewicht.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Media spelen een belangrijke rol in het functioneren van het Nederlandse parlement. Kamerleden zijn veelal nieuwsjunkies en de berichtgeving die zij consumeren speelt daardoor een rol in hun dagelijks werk. Zo hebben diverse onderzoekers aangetoond dat media-aandacht een sterke invloed heeft op zogenaamde…

Wat beïnvloedt het gedrag van verantwoordingsforums?

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Op 16 december promoveert Ruixue Wu. Het Leiden University Centre for Linguistics feliciteert Ruixue!

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Op 17 oktober verdedigde Annelies van Vark het proefschrift 'Separation and immersion: the changing role of the armed forces in Northwestern liberal democracies'. Het promotieonderzoek is begeleid door Maartje van der Woude en Erwin Muller.

In dit artikel onderzoekt Amandine Lerusse hoe de volgorde van prestatie-informatie de prioriteringsbeslissingen van lokale politici beïnvloedt.

Bernard Bernards onderzoekt beperkingen op innovatie door te focussen op cognitieve onzekerheid als toestand die innovatief werkgedrag kan beïnvloeden.

Promotie

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Op 23 juni 2019 verdedigde Zygimantas Juska zijn proefschrift 'The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law'. Het promotieonderzoek is begeleid door promotor prof. dr. T.R Ottervanger.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.