At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

We are living in an information era where the amount of image and video data increases exponentially.

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

Dit onderzoeksprogramma brengt door het verkennen van de grenzen van het internationaal publiekrecht deze verandering van de internationale rechtsorde in kaart.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotie

Wil je gezond en energiek aan het werk en met een positief gevoel je werkdag beëindigen, maar lukt dat niet altijd? Healthy University Leiden werkt samen met jou aan een gezonde en prettige werkomgeving waar je je optimaal kunt ontwikkelen.

Pre-University Classes zijn bedoeld voor vwo-leerlingen uit de bovenbouw die meer willen en kunnen dan in het reguliere schoolprogramma wordt aangeboden. In de classes volgen de leerlingen speciale collegereeksen en maken op die manier kennis met de wereld van de wetenschap.

Heb je een brede belangstelling en vind je het leuk om meer te doen naast je gewone schoolwerk? Dan wil jij vast altijd het naadje van de kous weten! Dat is precies wat het Pre-University College is: een extra programma voor leerlingen die meer willen en kunnen.

Werken en studeren doe je op de universiteit, maar ook thuis. Deze hybride manier van werken brengt een aantal uitdagingen met zich mee. Hier vind je tips en tricks om op een gezonde en verantwoorde manier thuis en op de universiteit te studeren en werken.

Het Leiden University Green Office (LUGO) ondersteunt de universiteit in haar duurzaamheidstransitie door duurzaamheid in onderwijs, onderzoek en bedrijfsvoering te stimuleren.

Welkom bij Leiden University Green Office!

Master

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Promotor: G.P. van Wezel

Curved single crystals provide variable, but well-defined surface structures.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: C.J. ten Cate

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Media spelen een belangrijke rol in het functioneren van het Nederlandse parlement. Kamerleden zijn veelal nieuwsjunkies en de berichtgeving die zij consumeren speelt daardoor een rol in hun dagelijks werk. Zo hebben diverse onderzoekers aangetoond dat media-aandacht een sterke invloed heeft op zogenaamde…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Op 12 mei 2020 verdedigde Darryl Robinson zijn proefschrift 'Exploring Justice in Extreme Cases: Criminal Law Theory and International Criminal Law'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

This dissertation focuses on investigating the public communication around quantum science and technology that may affect public engagement.

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

Wat is mijn bijdrage aan onze wereld? Dat is de vraag die studenten en onderzoekers van het Leiden University College The Hague (LUC) zichzelf dagelijks stellen. Ze willen in hun onderwijs en onderzoek stappen vooruitzetten op het gebied van de vier global challenges ‘Peace and justice’, ‘Sustainability’,…

Leiden University College (LUC), een instituut van de Universiteit Leiden in Den Haag – de internationale stad van vrede, recht en veiligheid – biedt sinds 2010 de Engelstalige bacheloropleiding Liberal Arts and Sciences: Global Challenges. Geïnspireerd door het Amerikaanse university college-model…