Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

The Role and Effectiveness of the G20. In dit artikel, gepubliceerd in The Changing Global Order onderdeel van the United Nations University Series on Regionalism book series, bespreekt auteur Jaroslaw Kantorowicz de evolutie van de G20.

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Promotor: Prof.dr. H.V.J. Linnartz

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

EUMOTIONS onderzoekt welke rol emoties van politieke elites (op EU- en lidstaatniveau) spelen in het formuleren van beleidsmogelijkheden van de EU tijdens internationale crises.

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

In dit artikel wordt betoogd dat de weerstand tegen groene overheidsinvesteringen afhankelijk is van de wijze van financiering.

Alessandro Tonutti heeft op 5 september 2017 zijn proefschrift:

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

De afdeling richt zich op het verbeteren van het wetenschappelijk begrip in de relatie tussen mens en natuur. Hoe beïnvloedt menselijk handelen (via bijvoorbeeld klimaatverandering, landgebruiksverandering en de emissie van mogelijk toxische verbindingen) de natuur in het algemeen en de biodiversiteit…

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotor: W.T. de Groot

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Consequences for sediment stability and seston trapping

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

De Universiteit Leiden houdt haar drinkwaterverbruik zo laag mogelijk.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Metal production is not only energy-intensive and a major source of greenhouse gas (GHG) emissions, but is also associated with other impacts affecting human health and ecosystems.

Academici hebben op het gebied van inlichtingen geworsteld met de vraag onder welke voorwaarden internationale samenwerking op het gebied van inlichtingen plaatsvindt. De meeste richten zich op transactionele motieven en gegarandeerde opbrengsten, de zogenaamde ‘Quid pro Quo’. Tegelijkertijd wordt vertrouwen…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Dit proefschrift richt zich op de opvattingen en percepties van Chinese en Nederlandse docenten over de rol van onderzoek in het hoger onderwijs.

Het doel van dit proefschrift was om mogelijke risicofactoren voor overgewicht in de vroege kindertijd te ontdekken die als basis kunnen worden gebruikt voor het ontwikkelen van opvoedinterventies voor het verminderen van overgewicht.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Media spelen een belangrijke rol in het functioneren van het Nederlandse parlement. Kamerleden zijn veelal nieuwsjunkies en de berichtgeving die zij consumeren speelt daardoor een rol in hun dagelijks werk. Zo hebben diverse onderzoekers aangetoond dat media-aandacht een sterke invloed heeft op zogenaamde…