The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Patterned detectors are an existing technology that can be found in almost all color cameras.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Kunst en vrije tijd, Kunst en vrije tijd

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: Roeland M.H. Merks

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

De gebouwen van de Faculteit Geesteswetenschappen in de binnenstad van Leiden worden één voor één aangepakt. Na de gerenoveerde gebouwen P.J. Veth, Arsenaal en Herta Mohr, wordt nu gewerkt aan het ontwerp voor het gebouw Aleida Nijland (voorheen Matthias de Vrieshof / Cluster Noord).

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

De Universiteit Leiden bouwt aan haar toekomst in Leiden. Daarom investeert de universiteit de komende jaren ruim 100 miljoen euro in de vernieuwing van de gebouwen van de Faculteit Geesteswetenschappen, aan de Witte Singel en de Doelenzijde. Met deze nieuwe Humanities Campus, nauw verbonden met…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

De Universiteit Leiden werkt aan een groene, circulaire campus, met een forse energiereductie in 2050 als doel, zoals uitgewerkt in de in 2022 verschenen Routekaart energietransitie gebouwen.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Het Leiden Bio Science Park (LBSP) is het grootste innovatiedistrict van Nederland op het gebied van Life Sciences & Health. De clustering van hoogwaardig onderwijs, onderzoek, zorg en bedrijfsleven trekt studenten, wetenschappers en ondernemers vanuit de hele wereld naar kennisstad Leiden.

Den Haag is, naast Leiden, de tweede moederstad van de Universiteit Leiden.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Duurzaamheid op de campus, energietransitie, groen, circulair

In dit artikel onderzoeken Wout Broekema, Wouter Jong en Sara Perlstein het ontwerp en de beoordeling van crisisonderzoeken vanuit een leerperspectief.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Wijnhaven, Turfmarkt 99, 2511 DP, Den Haag

In dit artikel onderzoeken Thijs van Dooremalen en Philip Smith hoe het publieke discours over hittegolven is verschoven in Britse kranten.

Lezing

The global agri-food system plays a critical role in food security and environmental issues.

Promotores: S.F. Portegies Zwart, E. M. Rossi

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

In this thesis, we present new laboratory data of interstellar dust analogues.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…