473 zoekresultaten voor “knowledge transfer” in de Publieke website
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Control of Western flower thrips through jasmonate-triggered plant immunity
We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.
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Control of early plant development by light quality
This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants.
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Resource Panel
Contributions to the UNEP international panel for sustainable resource management
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PUMA (Prospecting the Urban Mines of Amsterdam)
PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?
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Studying through the summer?
Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…
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Accessible remote sensing of water
Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.
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Assessing global regionalized impacts of eutrophication on freshwater fish biodiversity
Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.
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Surface-structure dependencies in catalytic reactions
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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Consortium RawMatTERS wint innovatieprijs
Het consortium RawMatTERS, waar de Universiteit Leiden deel van uitmaakt, heeft de ‘Knowledge and Innovation Communities (KIC) Raw Materials’ gewonnen. Deze prijs is bestemd voor innovatief onderzoek naar grondstoffen.
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aligning people, technology and practice through collaboration and knowledge sharing
Promotie
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Wiskunde en Natuurwetenschappen
De Faculteit Wiskunde en Natuurwetenschappen
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2 PhD Candidates, Reinforcement Learning for Sustainable Energy
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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PhD in Formal Methods for Quantum Compilation (1.0 FTE)
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Solution for Critical Raw Materials - an European Export Network (SCRREEN)
Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.
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Master Track Public Administration: Economics and Governance
The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…
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Rechtsgeleerdheid: eLaw
eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?
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Parttime programma
Sinds 2021 is de master ook in deeltijd te volgen, een parttime opleiding van 2-3 dagen per week, waarvan één vaste, verplichte dag op vrijdag.
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Multi-Objective Bayesian Global Optimization for Continuous Problems and Applications
A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Expanding the coverage of ecosystem services in life cycle assessment: an interdisciplinary venture
To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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X-ray spectroscopy of merging galaxy clusters
This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Evaluation of Different Design Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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The noise of the hunt: effects of noise on predator-prey relationships in a marine ecosystem
The effects of anthropogenic noise on interactions between predators and their prey are still little understood.
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Materials Innovative Technologies Assessment (MIN-TEA)
How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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Understanding the value of social media metrics for research evaluation
The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.
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Electrochemical and surface studies of the effect of naphthalene-based additives on tin electrodeposition
Tin electrodeposition applications have rapidly evolved in the past 25 years.
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Optimal decision-making under constraints and uncertainty
We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Balsaminaceae in Southeast Asia: systematics, evolution, and pollination biology
Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.
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Glycosyl Cations in Glycosylation Reactions
This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.
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Het implementeren van een nationale wiskunde onderwijsvernieuwing in China
Dit project richt zich op het implementeren van een nationale wiskunde onderwijsvernieuwing in het Chinese voortgezet onderwijs. Het onderzoek beoogt bij te dragen aan begrip van en verklaringen voor de manieren waarop wiskunde leraren een nationale wiskunde vernieuwing implementeren en hoe de vernieuwing…