In het programma Time Warp brengt bioloog Freek Vonk de gevaarlijkste gifslangen ter wereld voor de camera. Zijn doel is niet het tonen alleen, maar vooral het melken van het slangengif ten behoeve van zijn promotieonderzoek. Vrijdag vertelde hij over zijn fascinatie voor slangen in 'De Wereld Draait…

Op vrijdagavond 17 september is de Leidse astronoom Joe Callingham te zien in een nieuwe serie op Discovery. ‘Killers of The Cosmos’ gaat over krachten in het heelal die ons bestaan kunnen bedreigen. Asteroïden, kosmisch puin, elektromagnetische wapens… De show behandelt elke bedreiging als potentiële…

Jasmina Mačkić, universitair docent aan het Europa Instituut, presenteerde haar onderzoek tijdens ‘The Dissident’, een live talk show die regelmatig wordt georganiseerd door World-Talks, op 24 mei 2018. De bijeenkomst draaide om de Nigeriaanse mensenrechtenactivist Justus Ijeoma, de oprichter van de…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: T.H. Oosterkamp

Bij een medische behandeling geldt een aantal rechten en plichten voor u en voor de arts of specialist. U hebt bijvoorbeeld het recht uw medisch dossier in te zien. De arts moet u bijvoorbeeld informeren over behandeling en onderzoek. U en de zorgverlener zijn verplicht zich aan de regels te houden.

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

In Chapter 1 we provide some background information about modular forms, describe the correspondence between half-integral and integer weight modular forms and explain how the coefficients of half-integral weight modular forms encode the central values of L-functions of twisted modular forms.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: Prof.dr. M.K. Richardson

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: B. van de Water

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.