The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Het onderzoeksprogramma Probability Theory richt zich op kansrekening en op operationeel onderzoek.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

Het onderzoek binnen het Algebra, Geometry and Number Theory programma varieert van fundamentele wiskundige theorie tot algoritmes en toepassingen.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

In de masterspecialisatie Algebra, Geometry and Number Theory verbreed je je kennis van de zuivere wiskunde met onderwerpen als getaltheorie, algebraïsche meetkunde, algebraïsche topologie en cryptologie.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

In deze masterspecialisatie houd je je bezig met twee kernthema’s in de politieke filosofie: legitimiteit en rechtvaardigheid. Je verdiept je in theoriën, methoden en complexe casus en maakt de stap van opinie naar analyse.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

This six-weeks online course delves into the research behind terrorism as it unpacks the assumptions and impacts of both terrorism and counterterrorism.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Promotor: J. Zaanen

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotor: Prof.dr. G.P. van Wezel

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

In deze studie onderzoeken we of 2-3-jarigen in staat zijn te anticiperen op het gedrag van een personage door rekening te houden met wat dit personage wel of niet weet over de situatie. Het kind zit op schoot en krijgt animaties te zien met twee personages, waarbij de ene zich verstopt en de andere…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

Het boek biedt verschillende theoretische perspectieven om het proces van publieke sector hervormingen te onderzoeken. Daarnaast geeft het een overzicht van de belangrijkste trends in publieke sector hervormingen in Europa en de Verenigde Staten.

Het onderzoek gaat over de vraag op welke wijze en op welk niveau studenten van de opleiding voor leraar basisonderwijs theorie en praktijk kunnen integreren en hoe de inrichting van hun leeromgeving, toegespitst op het vak rekenen-wiskunde en didactiek, daaraan kan bijdragen.

Op 16 april 2020 verdedigde Andrew Fink zijn proefschrift 'The Importance of Conspiracy Theory in Extremist Ideology and Propaganda'. Het promotieonderzoek is begeleid door promotor prof.dr. A. Ellian.

In this thesis we construct an extension associated with the Furstenberg compactification of symmetric space of noncompact type. From this extension we get a cycle in equivariant KK-theory representing the extension. The construction of the extension and the corresponding cycle is a generalization of…

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.