Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Onderzoeksgroepen in het Biological & Soft Matter onderzoeksprogramma ontrafelen de mechanismen in biologische processen en ontwikkelen nieuwe zachte materialen die geïnspireerd zijn door de natuur.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

In deze master specialisatie ligt de focus op het begrijpen van biologische processen in hun natuurlijke context, zoals cellen en weefsels.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Promotores: H. Schiessel, G.T. Barkema

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

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Jessica Vance Roitman en Wouter Veenendaal, onderzoekers aan het Koninklijk Instituut voor Taal-, Land- en Volkenkunde (KITLV)/Royal Netherlands Institute of Southeast Asian and Caribbean Studies, onderzoeken de oorsprong, ontwikkeling en consolidatie van politieke oligrachie op St. Maarten. Doorgaans…

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The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

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This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

De DASPO-groep voor data-analyse en overleving in kanker aan het Mathematisch Instituut heeft een app ontwikkeld die persoonlijke prognoses verschaft voor patiënten met zachtweefselsarcoom. Door de agressieve aard van dergelijke tumoren is de prognose voor deze patiënten slecht, zelfs na een operatie…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Intensive care-afdelingen overal ter wereld kunnen hun doseringen voor morfine bij baby’s en peuters gaan aanpassen. Met een nieuwe methode ontdekte farmacologe Elke Krekels dat gebruikelijke doseringen bij pasgeborenen te hoog zijn, en bij peuters juist te laag. Promotie 10 oktober.

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Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: Prof.dr. J.N. Kok

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Promotor: Prof.dr. L.J. Slikkerveer

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Promotor: Prof.dr. J.N. Kok

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. T. Hankemeier

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

De STAP-studie onderzoekt de kosteneffectiviteit van Written Exposure Therapy (WET) voor PTSS-symptomen in de huisartsenpraktijk.