At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Dit onderzoeksprogramma brengt door het verkennen van de grenzen van het internationaal publiekrecht deze verandering van de internationale rechtsorde in kaart.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

Promotor: C.J. ten Cate

Promotor: G.P. van Wezel

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

We are living in an information era where the amount of image and video data increases exponentially.

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Media spelen een belangrijke rol in het functioneren van het Nederlandse parlement. Kamerleden zijn veelal nieuwsjunkies en de berichtgeving die zij consumeren speelt daardoor een rol in hun dagelijks werk. Zo hebben diverse onderzoekers aangetoond dat media-aandacht een sterke invloed heeft op zogenaamde…

Which characteristics are crucial in adaptation and speciation? How did ecological speciation took place?

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Op 12 mei 2020 verdedigde Darryl Robinson zijn proefschrift 'Exploring Justice in Extreme Cases: Criminal Law Theory and International Criminal Law'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Overkleeft

Promotie

Curved single crystals provide variable, but well-defined surface structures.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Sociale Wetenschappen, Pedagogische Wetenschappen

Sensatieverhalen vertellen, voordelen overdrijven en risico's onderschatten: ergens een 'hype' over creëren klinkt niet als iets waar een verantwoordelijke wetenschapper zich aan zou wagen. Of kunnen we een hype ook op een 'goede manier' inzetten? Wat kunnen we bereiken door discussies over de quantumtoekomst…

Promotor: J. Zaanen, Co-Promotor: V. Juricic

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Rottgering

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Op 3 december 2019 verdedigde Meda Couzens haar proefschrift 'The application of the United Nations Convention on the Rights of the Child by national courts'. Het promotieonderzoek is begeleid door promotoren prof.dr. T. Liefaard en prof.mr. J.J. Sloth-Nielsen.